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    isoQC iso Glutaminyl cyclase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40270, updated on 9-Dec-2024

    Summary

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    Official Symbol
    isoQCprovided by FlyBase
    Official Full Name
    iso Glutaminyl cyclaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036999
    Locus tag
    Dmel_CG5976
    See related
    AllianceGenome:FB:FBgn0036999
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32426; CG5976; Dmel\CG5976; isoDromeQC
    Summary
    Enables glutaminyl-peptide cyclotransferase activity. Located in extracellular region and mitochondrion. Is expressed in adult head. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase) and QPCTL (glutaminyl-peptide cyclotransferase like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See isoQC in Genome Data Viewer
    Location:
    77C4-77C4; 3-47 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20474466..20477003)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20467566..20470103)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene L-threonine dehydrogenase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Zinc transporter 77C Neighboring gene NADH dehydrogenase (ubiquinone) 39 kDa subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of glutaminyl cyclases (QCs) from Drosophila melanogaster reveal active site conservation between insect and mammalian QCs. Koch B, et al. Biochemistry, 2012 Sep 18. PMID 22897232
    2. Isolation and characterization of glutaminyl cyclases from Drosophila: evidence for enzyme forms with different subcellular localization. Schilling S, et al. Biochemistry, 2007 Sep 25. PMID 17722885
    3. Molecular evolution and population genetic analysis of candidate female reproductive genes in Drosophila. Panhuis TM, et al. Genetics, 2006 Aug. PMID 16783023, Free PMC Article
    4. What model organisms and interactomics can reveal about the genetics of human obesity. Williams MJ, et al. Cell Mol Life Sci, 2012 Nov. PMID 22618246, Free PMC Article
    5. From fat fruit fly to human obesity. Smith WW, et al. Physiol Behav, 2014 Sep. PMID 24508822, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables glutaminyl-peptide cyclotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutaminyl-peptide cyclotransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables glutaminyl-peptide cyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    iso glutaminyl cyclase
    Names
    CG5976-PA
    CG5976-PB
    isoQC-PA
    isoQC-PB
    NP_788550.1
    NP_788551.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20474466..20477003
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176372.2 → NP_788550.1  iso glutaminyl cyclase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788550.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KTY3, Q86PD7
      UniProtKB/TrEMBL
      Q0GT88
      Related
      FBpp0077857
      Conserved Domains (1) summary
      cd03880
      Location:56 → 346
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

    2. NM_176373.3 → NP_788551.1  iso glutaminyl cyclase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788551.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0GT88, Q0GT99
      Related
      FBpp0077858
      Conserved Domains (1) summary
      cd03880
      Location:54 → 344
      M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86PD7.1 Q86PD7

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