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    conu conundrum [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3355133, updated on 9-Dec-2024

    Summary

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    Official Symbol
    conuprovided by FlyBase
    Official Full Name
    conundrumprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039994
    Locus tag
    Dmel_CG17082
    See related
    AllianceGenome:FB:FBgn0039994
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LD04957; CG17082; CG40286; Conu; Dmel\CG17082
    Summary
    Enables GTPase activator activity. Involved in positive regulation of cell population proliferation. Located in apical cortex. Is expressed in organism. Human ortholog(s) of this gene implicated in allergic disease and schizophrenia. Orthologous to human ARHGAP18 (Rho GTPase activating protein 18); ARHGAP28 (Rho GTPase activating protein 28); and ARHGAP40 (Rho GTPase activating protein 40). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See conu in Genome Data Viewer
    Location:
    41C1-41C1; 2-55 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (4744348..4758048)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (631853..645553)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45471 Neighboring gene pseudo Neighboring gene pseudo Neighboring gene long non-coding RNA:CR46064 Neighboring gene pseudo Neighboring gene long non-coding RNA:CR46478 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Feedback inhibition of actin on Rho mediates content release from large secretory vesicles. Segal D, et al. J Cell Biol, 2018 May 7. PMID 29496739, Free PMC Article
    2. Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin. Neisch AL, et al. Mol Biol Cell, 2013 May. PMID 23468526, Free PMC Article
    3. The Green Valley of Drosophila melanogaster Constitutive Heterochromatin: Protein-Coding Genes Involved in Cell Division Control. Messina G, et al. Cells, 2022 Sep 29. PMID 36231024, Free PMC Article
    4. RhoGAP19D inhibits Cdc42 laterally to control epithelial cell shape and prevent invasion. Fic W, et al. J Cell Biol, 2021 Apr 5. PMID 33646271, Free PMC Article
    5. Prepatterning by RhoGEFs governs Rho GTPase spatiotemporal dynamics during wound repair. Nakamura M, et al. J Cell Biol, 2017 Dec 4. PMID 28923977, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Moesin interacts with an unusual RhoGAP, Conundrum (Conu), and recruits it to the cell cortex to negatively regulate RhoA activity.
      Title: Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: 4748502-4748577 mobile_element_type = transposon:INE-1{}4388
    • Loc: 4750399-4751495 mobile_element_type = transposon:1360{}5000
    • Loc: 4751587-4751642 mobile_element_type = transposon:INE-1{}4391
    • Loc: 4752406-4753474 mobile_element_type = transposon:Rt1c{}5065
    • Loc: 4754933-4755362 mobile_element_type = transposon:Cr1a{}5025

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of actin filament polymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of small GTPase mediated signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical cortex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    conundrum
    Names
    CG17082-PA
    CG17082-PB
    CG17082-PD
    CG17082-PG
    CG17082-PI
    conu-PA
    conu-PB
    conu-PD
    conu-PG
    conu-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      4744348..4758048
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042992.2 → NP_001036457.1  conundrum, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036457.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E9Q3, Q8T0G4
      UniProtKB/TrEMBL
      C9QP26
      Conserved Domains (1) summary
      cd04391
      Location:356 → 576
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    2. NM_001042990.3 → NP_001036455.2  conundrum, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036455.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E9Q3, Q8T0G4
      UniProtKB/TrEMBL
      C9QP26
      Conserved Domains (1) summary
      cd04391
      Location:356 → 576
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    3. NM_001042989.3 → NP_001036454.1  conundrum, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036454.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E9Q3, Q8T0G4
      UniProtKB/TrEMBL
      C9QP26
      Conserved Domains (1) summary
      cd04391
      Location:356 → 576
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    4. NM_001042993.3 → NP_001036458.1  conundrum, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036458.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E9Q3, Q8T0G4
      UniProtKB/TrEMBL
      C9QP26
      Conserved Domains (1) summary
      cd04391
      Location:356 → 576
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...

    5. NM_001042991.3 → NP_001036456.3  conundrum, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036456.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0E9Q3, Q8T0G4
      UniProtKB/TrEMBL
      C9QP26
      Conserved Domains (1) summary
      cd04391
      Location:356 → 576
      RhoGAP_ARHGAP18; RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8T0G4.1 Q8T0G4

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