Ecrg4 ECRG4 augurin precursor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ecrg4provided by RGD
Official Full Name: ECRG4 augurin precursorprovided by RGD
Primary source: RGD:1305645
See related: EnsemblRapid:ENSRNOG00000023576 AllianceGenome:RGD:1305645
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1305645
Summary: Predicted to enable neuropeptide hormone activity. Involved in negative regulation of cell population proliferation and response to wounding. Located in extracellular space. Orthologous to human ECRG4 (ECRG4 augurin precursor). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 208.6), Uterus (RPKM 164.2) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (53485040..53504691)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (45992954..46012605)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (50526811..50548056)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ur identification of ECRG4 in many structures suggests the involvement of ECRG4 in the tumorigenesis of other organs
Title: ECRG4 expression in normal rat tissues: expression study and literature review.
Ecrg4 plays a role in coordinating the inflammatory and proliferative response to infection of mucosal epithelium suggesting a possible mechanism for its putative anti-tumor activity.
Title: Ecrg4 attenuates the inflammatory proliferative response of mucosal epithelial cells to infection.
Augurin would play a constitutive inhibitory function in normal CNS while down regulation of Ecrg4 gene expression in injury, like in cancer, dysinhibits proliferation.
Title: Esophageal cancer related gene-4 is a choroid plexus-derived injury response gene: evidence for a biphasic response in early and late brain injury.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G1 to G0 transition	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within G1 to G0 transition	ISO Inferred from Sequence Orthology more info
involved_in anaphase-promoting complex-dependent catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anaphase-promoting complex-dependent catabolic process	ISO Inferred from Sequence Orthology more info
involved_in cellular senescence	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular senescence	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in central nervous system development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticosterone secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticotropin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of corticotropin-releasing hormone secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to wounding	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vasopressin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in dense core granule	ISO Inferred from Sequence Orthology more info
located_in dense core granule	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: augurin

Names: esophageal cancer related gene 4 protein; esophageal cancer-related gene 4 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.