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    tolA Tol-Pal system protein TolA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946625, updated on 3-Dec-2024

    Summary

    Official Symbol
    tolA
    Official Full Name
    Tol-Pal system protein TolA
    Primary source
    ECOCYC:EG11007
    Locus tag
    b0739
    See related
    ASAP:ABE-0002515
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    cim; ECK0728; excC; lky; tol-2
    Summary
    Cell envelope integrity is stabilized by the Tol-Pal system linking inner and outer membranes. [More information is available at EcoGene: EG11007]. TolA is one of three (along with TolQ and TolR) inner membrane protein members of the YbgC-YbgF-TolQ-R-A-B-Pal Cell Envelope Complex, also known as the Tol-Pal system. [More information is available at EcoCyc: EG11007].
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    Genomic context

    Sequence:
    NC_000913.3 (776342..777607)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene esterase/thioesterase Neighboring gene Tol-Pal system protein TolQ Neighboring gene Tol-Pal system protein TolR Neighboring gene Tol-Pal system periplasmic protein TolB Neighboring gene peptidoglycan-associated outer membrane lipoprotein Pal

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables disordered domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables toxin transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables virion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    PubMed 

    General protein information

    Preferred Names
    Tol-Pal system protein TolA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      776342..777607
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415267.1 Tol-Pal system protein TolA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415267.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8I0CBZ0
      Conserved Domains (1) summary
      PRK09510
      Location:1421
      tolA; cell envelope integrity inner membrane protein TolA; Provisional