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    ZNF133 zinc finger protein 133 [ Homo sapiens (human) ]

    Gene ID: 7692, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF133provided by HGNC
    Official Full Name
    zinc finger protein 133provided by HGNC
    Primary source
    HGNC:HGNC:12917
    See related
    Ensembl:ENSG00000125846 MIM:604075; AllianceGenome:HGNC:12917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF150; pHZ-13; pHZ-66
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in skin (RPKM 1.6), ovary (RPKM 1.5) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF133 in Genome Data Viewer
    Location:
    20p11.23
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (18288527..18316996)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (18339617..18368084)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (18269171..18297640)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904876 Neighboring gene uncharacterized LOC105372551 Neighboring gene RNA, U2 small nuclear 56, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17581 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:18268873-18269778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17583 Neighboring gene RN7SK pseudogene 74 Neighboring gene ZNF133 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:18304193-18304816 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr20:18309992-18311191 Neighboring gene RNY4 pseudogene 11 Neighboring gene small nucleolar RNA U13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF133 is associated with infliximab responsiveness in patients with inflammatory bowel diseases. Jung ES, et al. J Gastroenterol Hepatol, 2019 Oct. PMID 30851117
    2. Human alcoholism studies of genes identified through mouse quantitative trait locus analysis. Ehringer MA, et al. Addict Biol, 2002 Oct. PMID 14578011
    3. ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression. Li L, et al. Oncogene, 2023 Jun. PMID 37221223
    4. PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity. Lee SJ, et al. Exp Mol Med, 2007 Aug 31. PMID 17934332
    5. Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a KrĂĽppel-type zinc finger factor. Moosmann P, et al. Biol Chem, 1997 Jul. PMID 9278146

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
      Title: ZNF133 is a potent suppressor in breast carcinogenesis through dampening L1CAM, a driver for tumor progression.
    2. ZNF133 SNPs are associated with infliximab responsiveness in patients crohn's disease and ulcerative colitis.
      Title: ZNF133 is associated with infliximab responsiveness in patients with inflammatory bowel diseases.
    3. the transcriptional repressor activity of ZNF133 is regulated by both the KRAB domain and the zinc finger motifs, and that the repressive effect by zinc finger motifs is mediated by PIAS1
      Title: PIAS1 interacts with the KRAB zinc finger protein, ZNF133, via zinc finger motifs and regulates its transcriptional activity.
    4. response to alcohol may be expressed by one of these candidate genes, zinc finger 133 (Znf133
      Title: Human alcoholism studies of genes identified through mouse quantitative trait locus analysis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 133
    Names
    zinc finger protein 133 (clone pHZ-13)
    zinc finger protein 150 (pHZ-66)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083330.4 → NP_001076799.2  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. NM_001282995.3 → NP_001269924.2  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Related
      ENSP00000400897.3, ENST00000396026.7
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. NM_001282996.3 → NP_001269925.2  zinc finger protein 133 isoform b

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (3) summary
      smart00349
      Location:4 → 63
      KRAB; krueppel associated box
      COG5048
      Location:232 → 641
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:289 → 309
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_001282997.3 → NP_001269926.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Related
      ENSP00000383945.1, ENST00000401790.6
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. NM_001282998.3 → NP_001269927.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    6. NM_001282999.3 → NP_001269928.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    7. NM_001283000.3 → NP_001269929.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Related
      ENSP00000481326.1, ENST00000622607.4
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    8. NM_001283001.3 → NP_001269930.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    9. NM_001283002.3 → NP_001269931.2  zinc finger protein 133 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63233.1
      Related
      ENSP00000487315.1, ENST00000628216.2
      Conserved Domains (3) summary
      smart00349
      Location:4 → 63
      KRAB; krueppel associated box
      COG5048
      Location:218 → 627
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:275 → 295
      ZF_C2H2; C2H2 Zn finger [structural motif]

    10. NM_001283003.3 → NP_001269932.2  zinc finger protein 133 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:152 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    11. NM_001283004.3 → NP_001269933.2  zinc finger protein 133 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:152 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    12. NM_001283005.3 → NP_001269934.2  zinc finger protein 133 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS74703.2
      Related
      ENSP00000485741.1, ENST00000630056.1
      Conserved Domains (2) summary
      COG5048
      Location:120 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:177 → 197
      ZF_C2H2; C2H2 Zn finger [structural motif]

    13. NM_001283006.3 → NP_001269935.2  zinc finger protein 133 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS74703.2
      Conserved Domains (2) summary
      COG5048
      Location:120 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:177 → 197
      ZF_C2H2; C2H2 Zn finger [structural motif]

    14. NM_001283007.3 → NP_001269936.2  zinc finger protein 133 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS74703.2
      Related
      ENSP00000439427.3, ENST00000535822.6
      Conserved Domains (2) summary
      COG5048
      Location:120 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:177 → 197
      ZF_C2H2; C2H2 Zn finger [structural motif]

    15. NM_001283008.3 → NP_001269937.2  zinc finger protein 133 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS74703.2
      Conserved Domains (2) summary
      COG5048
      Location:120 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:177 → 197
      ZF_C2H2; C2H2 Zn finger [structural motif]

    16. NM_001352450.2 → NP_001339379.2  zinc finger protein 133 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:152 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    17. NM_001352451.2 → NP_001339380.2  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    18. NM_001352452.2 → NP_001339381.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Related
      ENSP00000406638.2, ENST00000425686.3
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    19. NM_001352453.2 → NP_001339382.2  zinc finger protein 133 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS74703.2
      Conserved Domains (2) summary
      COG5048
      Location:120 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:177 → 197
      ZF_C2H2; C2H2 Zn finger [structural motif]

    20. NM_001352454.2 → NP_001339383.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    21. NM_001352455.2 → NP_001339384.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    22. NM_001352456.2 → NP_001339385.2  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    23. NM_001352457.2 → NP_001339386.2  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    24. NM_001352458.2 → NP_001339387.2  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    25. NM_001352459.2 → NP_001339388.2  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    26. NM_001352460.2 → NP_001339389.2  zinc finger protein 133 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:152 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    27. NM_001352461.2 → NP_001339390.2  zinc finger protein 133 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:152 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    28. NM_001352462.2 → NP_001339391.2  zinc finger protein 133 isoform k

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:151 → 560
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:208 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]

    29. NM_001352463.2 → NP_001339392.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    30. NM_001352464.2 → NP_001339393.2  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    31. NM_001387295.1 → NP_001374224.1  zinc finger protein 133 isoform l

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:252 → 661
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]

    32. NM_001387296.1 → NP_001374225.1  zinc finger protein 133 isoform m

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:251 → 660
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:308 → 328
      ZF_C2H2; C2H2 Zn finger [structural motif]

    33. NM_001387297.1 → NP_001374226.1  zinc finger protein 133 isoform n

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (3) summary
      smart00349
      Location:4 → 63
      KRAB; krueppel associated box
      COG5048
      Location:217 → 626
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:274 → 294
      ZF_C2H2; C2H2 Zn finger [structural motif]

    34. NM_001387298.1 → NP_001374227.1  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Related
      ENSP00000346090.3, ENST00000316358.8
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    35. NM_001387299.1 → NP_001374228.1  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    36. NM_001387300.1 → NP_001374229.1  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Related
      ENSP00000513883.1, ENST00000698704.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    37. NM_001387301.1 → NP_001374230.1  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    38. NM_001387302.1 → NP_001374231.1  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Related
      ENSP00000513884.1, ENST00000698705.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    39. NM_001387303.1 → NP_001374232.1  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    40. NM_001387304.1 → NP_001374233.1  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    41. NM_001387305.1 → NP_001374234.1  zinc finger protein 133 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS63234.1
      UniProtKB/Swiss-Prot
      A8K5S4, B4DHU7, B4DIB8, B7ZAS1, F5H289, J3KQ11, J3KQJ0, P52736, Q53XU1, Q5JXV8, Q9BUV2, Q9H443
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:215 → 624
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:272 → 292
      ZF_C2H2; C2H2 Zn finger [structural motif]

    42. NM_001387306.1 → NP_001374235.1  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    43. NM_001387307.1 → NP_001374236.1  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    44. NM_001387308.1 → NP_001374237.1  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    45. NM_001387309.1 → NP_001374238.1  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    46. NM_001387310.1 → NP_001374239.1  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    47. NM_001387311.1 → NP_001374240.1  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    48. NM_001387312.1 → NP_001374241.1  zinc finger protein 133 isoform o

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (3) summary
      smart00349
      Location:1 → 53
      KRAB; krueppel associated box
      COG5048
      Location:208 → 617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:265 → 285
      ZF_C2H2; C2H2 Zn finger [structural motif]

    49. NM_001387313.1 → NP_001374242.1  zinc finger protein 133 isoform p

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:183 → 592
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:240 → 260
      ZF_C2H2; C2H2 Zn finger [structural motif]

    50. NM_001387314.1 → NP_001374243.1  zinc finger protein 133 isoform q

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:182 → 591
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:239 → 259
      ZF_C2H2; C2H2 Zn finger [structural motif]

    51. NM_001387315.1 → NP_001374244.1  zinc finger protein 133 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:152 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    52. NM_001387316.1 → NP_001374245.1  zinc finger protein 133 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:152 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    53. NM_001387317.1 → NP_001374246.1  zinc finger protein 133 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:152 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    54. NM_001387318.1 → NP_001374247.1  zinc finger protein 133 isoform e

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:152 → 561
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:209 → 229
      ZF_C2H2; C2H2 Zn finger [structural motif]

    55. NM_001387319.1 → NP_001374248.1  zinc finger protein 133 isoform k

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Conserved Domains (2) summary
      COG5048
      Location:151 → 560
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:208 → 228
      ZF_C2H2; C2H2 Zn finger [structural motif]

    56. NM_001387320.1 → NP_001374249.1  zinc finger protein 133 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS74703.2
      Conserved Domains (2) summary
      COG5048
      Location:120 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:177 → 197
      ZF_C2H2; C2H2 Zn finger [structural motif]

    57. NM_001387321.1 → NP_001374250.1  zinc finger protein 133 isoform i

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS74703.2
      Conserved Domains (2) summary
      COG5048
      Location:120 → 529
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:177 → 197
      ZF_C2H2; C2H2 Zn finger [structural motif]

    58. NM_003434.7 → NP_003425.3  zinc finger protein 133 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL049646
      Consensus CDS
      CCDS13134.1
      Related
      ENSP00000366899.3, ENST00000377671.7
      Conserved Domains (3) summary
      smart00349
      Location:1 → 60
      KRAB; krueppel associated box
      COG5048
      Location:214 → 623
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:271 → 291
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. NR_178036.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      CP068258

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      18288527..18316996
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      18339617..18368084
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P52736.2 GenPept UniProtKB/Swiss-Prot:P52736

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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