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    FBXO34 F-box protein 34 [ Homo sapiens (human) ]

    Gene ID: 55030, updated on 27-Nov-2024

    Summary

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    Official Symbol
    FBXO34provided by HGNC
    Official Full Name
    F-box protein 34provided by HGNC
    Primary source
    HGNC:HGNC:20201
    See related
    Ensembl:ENSG00000178974 MIM:609104; AllianceGenome:HGNC:20201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Fbx34; CGI-301
    Summary
    Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in testis (RPKM 12.2), esophagus (RPKM 11.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FBXO34 in Genome Data Viewer
    Location:
    14q22.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (55271421..55443049)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (49476645..49562228)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (55738139..55820329)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ubiquitin conjugating enzyme E2 L1 (pseudogene) Neighboring gene cytochrome c oxidase subunit 5A pseudogene 1 Neighboring gene FBXO34 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5781 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8428 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:55754571-55754700 Neighboring gene ribosomal protein L34 pseudogene 28 Neighboring gene Sharpr-MPRA regulatory region 9702 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8430 Neighboring gene charged multivesicular body protein 4B pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8431 Neighboring gene NANOG hESC enhancer GRCh37_chr14:55794909-55795410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5782 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8432 Neighboring gene autophagy related 14 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5783 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 1 Neighboring gene ribosomal protein L21 pseudogene 6 Neighboring gene TATA-box binding protein like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8433 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:55914403-55915602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5784 Neighboring gene ribosomal protein L7a pseudogene 4 Neighboring gene abl interactor 1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation. Yang X, et al. Emerg Microbes Infect, 2022 Dec. PMID 36285453, Free PMC Article
    2. F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression. Tian X, et al. Oncotarget, 2015 Sep 8. PMID 26087183, Free PMC Article
    3. Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening. Falconieri A, et al. Cancers (Basel), 2022 Feb 17. PMID 35205757, Free PMC Article
    4. Composition and Regulation of the Cellular Repertoire of SCF Ubiquitin Ligases. Reitsma JM, et al. Cell, 2017 Nov 30. PMID 29103612, Free PMC Article
    5. Systematic analysis and nomenclature of mammalian F-box proteins. Jin J, et al. Genes Dev, 2004 Nov 1. PMID 15520277, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation.
      Title: FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20725, MGC126434, MGC126435, DKFZp547C162

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F-box only protein 34
    Names
    protein CGI-301

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017943.4 → NP_060413.2  F-box only protein 34

      See identical proteins and their annotated locations for NP_060413.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the more frequently occurring and longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AI911690, BC109120
      Consensus CDS
      CCDS32086.1
      UniProtKB/Swiss-Prot
      Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3
      UniProtKB/TrEMBL
      G3V2U9
      Related
      ENSP00000313159.4, ENST00000313833.5
      Conserved Domains (1) summary
      pfam12937
      Location:575 → 609
      F-box-like; F-box-like

    2. NM_152231.2 → NP_689417.1  F-box only protein 34

      See identical proteins and their annotated locations for NP_689417.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR, compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL158801
      Consensus CDS
      CCDS32086.1
      UniProtKB/Swiss-Prot
      Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3
      UniProtKB/TrEMBL
      G3V2U9
      Related
      ENSP00000394117.1, ENST00000440021.1
      Conserved Domains (1) summary
      pfam12937
      Location:575 → 609
      F-box-like; F-box-like

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      55271421..55443049
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006720185.4 → XP_006720248.1  F-box only protein 34 isoform X2

      See identical proteins and their annotated locations for XP_006720248.1

      UniProtKB/Swiss-Prot
      Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3
      UniProtKB/TrEMBL
      G3V2U9
      Related
      ENSP00000450877.1, ENST00000555280.1
      Conserved Domains (1) summary
      pfam12937
      Location:575 → 609
      F-box-like; F-box-like

    2. XM_017021391.2 → XP_016876880.1  F-box only protein 34 isoform X1

      UniProtKB/TrEMBL
      G3V2U9

    3. XM_017021393.3 → XP_016876882.1  F-box only protein 34 isoform X2

      UniProtKB/Swiss-Prot
      Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3
      UniProtKB/TrEMBL
      G3V2U9
      Conserved Domains (1) summary
      pfam12937
      Location:575 → 609
      F-box-like; F-box-like

    RNA

    1. XR_007064026.1 RNA Sequence

    2. XR_007064028.1 RNA Sequence

    3. XR_007064027.1 RNA Sequence

    4. XR_007064025.1 RNA Sequence

    5. XR_007064023.1 RNA Sequence

    6. XR_007064022.1 RNA Sequence

    7. XR_007064024.1 RNA Sequence

    8. XR_007064021.1 RNA Sequence

    9. XR_007064020.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      49476645..49562228
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054376283.1 → XP_054232258.1  F-box only protein 34 isoform X2

      UniProtKB/Swiss-Prot
      Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3

    2. XM_054376281.1 → XP_054232256.1  F-box only protein 34 isoform X1

    3. XM_054376282.1 → XP_054232257.1  F-box only protein 34 isoform X2

      UniProtKB/Swiss-Prot
      Q2VPB5, Q4VBP5, Q86TY4, Q9NWN3

    RNA

    1. XR_008488881.1 RNA Sequence

    2. XR_008488880.1 RNA Sequence

    3. XR_008488879.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NWN3.2 GenPept UniProtKB/Swiss-Prot:Q9NWN3

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