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    UBR4 ubiquitin protein ligase E3 component n-recognin 4 [ Homo sapiens (human) ]

    Gene ID: 23352, updated on 10-Dec-2024

    Summary

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    Official Symbol
    UBR4provided by HGNC
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 4provided by HGNC
    Primary source
    HGNC:HGNC:30313
    See related
    Ensembl:ENSG00000127481 MIM:609890; AllianceGenome:HGNC:30313
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p600; ZUBR1; RBAF600
    Summary
    The protein encoded by this gene is an E3 ubiquitin-protein ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in testis (RPKM 21.2), bone marrow (RPKM 14.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See UBR4 in Genome Data Viewer
    Location:
    1p36.13
    Exon count:
    108
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (19074510..19210266, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (18898062..19033778, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (19401004..19536760, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19248832-19249412 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 283 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19253369-19253995 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 285 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19259223-19260210 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:19261862-19262407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19262408-19262952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19262953-19263498 Neighboring gene intermediate filament family orphan 2 Neighboring gene Sharpr-MPRA regulatory regions 2400 and 6542 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19268377-19268894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 287 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19276675-19277594 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 290 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 291 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 348 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 347 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 349 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 293 Neighboring gene uncharacterized LOC105376815 Neighboring gene MPRA-validated peak97 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19334779-19335422 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:19337151-19338350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19338425-19339336 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19354797-19355297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19362307-19362878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19370112-19371086 Neighboring gene Sharpr-MPRA regulatory region 2200 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19396435-19397360 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19403898-19404066 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:19407589-19408788 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 295 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:19446050-19447249 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:19448647-19449846 Neighboring gene NANOG hESC enhancer GRCh37_chr1:19453252-19454051 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr1:19465867-19466616 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:19482517-19483716 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:19487245-19488444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19528831-19529332 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 296 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 297 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 351 Neighboring gene EMC1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:19562203-19562373 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:19577931-19578436 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19580253-19580754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:19580755-19581254 Neighboring gene ER membrane protein complex subunit 1 Neighboring gene MRT4 homolog, ribosome maturation factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. p600/UBR4 in the central nervous system. Parsons K, et al. Cell Mol Life Sci, 2015 Mar. PMID 25424645, Free PMC Article
    2. A novel locus for episodic ataxia:UBR4 the likely candidate. Conroy J, et al. Eur J Hum Genet, 2014 Apr. PMID 23982692, Free PMC Article
    3. Insights into the recognition mechanism in the UBR box of UBR4 for its specific substrates. Jeong DE, et al. Commun Biol, 2023 Nov 29. PMID 38030679, Free PMC Article
    4. Dengue virus co-opts UBR4 to degrade STAT2 and antagonize type I interferon signaling. Morrison J, et al. PLoS Pathog, 2013 Mar. PMID 23555265, Free PMC Article
    5. A new 1p36.13-1p36.12 microdeletion syndrome characterized by learning disability, behavioral abnormalities, and ptosis. Aagaard Nolting L, et al. Clin Genet, 2020 Jun. PMID 32170730

    See all (181) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease.
      Title: IKZF1 and UBR4 gene variants drive autoimmunity and Th2 polarization in IgG4-related disease.
    2. Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production.
      Title: Rift Valley fever virus Gn V5-epitope tagged virus enables identification of UBR4 as a Gn interacting protein that facilitates Rift Valley fever virus production.
    3. A new 1p36.13-1p36.12 microdeletion syndrome characterized by learning disability, behavioral abnormalities, and ptosis.
      Title: A new 1p36.13-1p36.12 microdeletion syndrome characterized by learning disability, behavioral abnormalities, and ptosis.
    4. UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD.
      Title: UBR E3 ligases and the PDIA3 protease control degradation of unfolded antibody heavy chain by ERAD.
    5. The endosomal recruitment of UBR4 is essential for the biogenesis of early endosomes and endosome-related processes.
      Title: The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome.
    6. Pathogenic mutation in UBR4 gene is associated with Episodic Ataxia.
      Title: Genetic Variants Associated with Episodic Ataxia in Korea.
    7. Ubiquitin ligase Ubr4 is a key component of the podocin interactome purified from podocytes. Ubiquitylation of one podocin site, K301, do not only target podocin for proteasomal degradation, but may also affect stability and disassembly of the multimeric complex.
      Title: The ubiquitin ligase Ubr4 controls stability of podocin/MEC-2 supercomplexes.
    8. Results showed KCMF1 C-terminus binds directly to RAD6, whereas N-terminal domains interact with UBR4 and point mutations found in X-linked intellectual disability (XLID) patients specifically lose the interaction with KCMF1 and UBR4.
      Title: KCMF1 (potassium channel modulatory factor 1) Links RAD6 to UBR4 (ubiquitin N-recognin domain-containing E3 ligase 4) and lysosome-mediated degradation.
    9. This review summarizes the central nervous system functions of p600 and proposes new perspectives on its biological complexity in neuronal physiology and neurological diseases.
      Title: p600/UBR4 in the central nervous system.
    10. Although UBR4 is not an ion channel gene, the potential for disrupted Ca(2+) control within neuronal cells highlights its potential for a role in this form of episodic ataxia.
      Title: A novel locus for episodic ataxia:UBR4 the likely candidate.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of ubiquitin protein ligase E3 component n-recognin 4 (UBR4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with ubiquitin protein ligase E3 component n-recognin 4 (UBR4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    Rev rev HIV-1 Rev interacting protein, ubiquitin protein ligase E3 component n-recognin 4 (UBR4), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with UBR4 is increased by RRE PubMed
    Vpr vpr The interaction of Vpr with DDB1 facilitates the formation of complexes containing Cul4A-Roc1 E3 ubiquitin ligase. The association of Vpr with DDB1-containing E3 ligase mediates the degradation of UNG2 and SMUG1 PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ41863, KIAA0462, KIAA1307

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasm protein quality control IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasm protein quality control by the ubiquitin-proteasome system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in endosome organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of HRI-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of fatty acid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of autophagy ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K27-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein stabilization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to oxidative stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in endosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane HDA PubMed 
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in specific granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in tertiary granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase UBR4
    Names
    N-recognin-4
    RING-type E3 ubiquitin transferase UBR4
    retinoblastoma-associated factor 600-like protein
    retinoblastoma-associated factor of 600 kDa
    zinc finger UBR1-type protein 1
    NP_065816.2
    XP_011539416.3
    XP_011539417.3
    XP_011539422.3
    XP_016856311.3
    XP_016856313.3
    XP_016856315.3
    XP_016856316.3
    XP_016856317.3
    XP_016856319.3
    XP_047272414.1
    XP_047272419.1
    XP_047272420.1
    XP_047272423.1
    XP_047272424.1
    XP_047272427.1
    XP_047272431.1
    XP_047272436.1
    XP_047272437.1
    XP_047272439.1
    XP_047272440.1
    XP_047272449.1
    XP_047272450.1
    XP_047272451.1
    XP_047272453.1
    XP_047272454.1
    XP_047272455.1
    XP_047272456.1
    XP_047272457.1
    XP_047272458.1
    XP_047272459.1
    XP_047272460.1
    XP_047272461.1
    XP_047272462.1
    XP_047272463.1
    XP_047272465.1
    XP_047272466.1
    XP_047272467.1
    XP_047272468.1
    XP_047272469.1
    XP_047272470.1
    XP_047272471.1
    XP_047272472.1
    XP_047272473.1
    XP_047272474.1
    XP_047272475.1
    XP_047272476.1
    XP_047272477.1
    XP_047272478.1
    XP_047272479.1
    XP_054191533.1
    XP_054191534.1
    XP_054191535.1
    XP_054191536.1
    XP_054191537.1
    XP_054191538.1
    XP_054191539.1
    XP_054191540.1
    XP_054191541.1
    XP_054191542.1
    XP_054191543.1
    XP_054191544.1
    XP_054191545.1
    XP_054191546.1
    XP_054191547.1
    XP_054191548.1
    XP_054191549.1
    XP_054191550.1
    XP_054191551.1
    XP_054191552.1
    XP_054191553.1
    XP_054191554.1
    XP_054191555.1
    XP_054191556.1
    XP_054191557.1
    XP_054191558.1
    XP_054191559.1
    XP_054191560.1
    XP_054191561.1
    XP_054191562.1
    XP_054191563.1
    XP_054191564.1
    XP_054191565.1
    XP_054191566.1
    XP_054191567.1
    XP_054191568.1
    XP_054191569.1
    XP_054191570.1
    XP_054191571.1
    XP_054191572.1
    XP_054191573.1
    XP_054191574.1
    XP_054191575.1
    XP_054191576.1
    XP_054191577.1
    XP_054191578.1
    XP_054191579.1
    XP_054191580.1
    XP_054191581.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027669.1 RefSeqGene

      Range
      4987..140743
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_020765.3 → NP_065816.2  E3 ubiquitin-protein ligase UBR4

      See identical proteins and their annotated locations for NP_065816.2

      Status: REVIEWED

      Source sequence(s)
      AA748129, AB007931, AB037728, AF348492, AL137127, AL357564
      Consensus CDS
      CCDS189.1
      UniProtKB/Swiss-Prot
      A8MPT2, A8MQ33, A8MQB1, O60646, O75050, Q4QRK5, Q5T4S7, Q5T4S8, Q5T4S9, Q5TBN8, Q5TBP2, Q6DKH8, Q6P4A4, Q7L8P7, Q8IXJ4, Q8TDN5, Q8WV67, Q9HA46, Q9P2N9, Q9UG82
      Related
      ENSP00000364403.3, ENST00000375254.8
      Conserved Domains (3) summary
      smart00396
      Location:1660 → 1727
      ZnF_UBR1; Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway
      pfam12773
      Location:3660 → 3704
      DZR; Double zinc ribbon
      pfam13764
      Location:4367 → 5163
      E3_UbLigase_R4; E3 ubiquitin-protein ligase UBR4

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      19074510..19210266 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416518.1 → XP_047272474.1  E3 ubiquitin-protein ligase UBR4 isoform X43

    2. XM_047416514.1 → XP_047272470.1  E3 ubiquitin-protein ligase UBR4 isoform X38

    3. XM_047416523.1 → XP_047272479.1  E3 ubiquitin-protein ligase UBR4 isoform X49

    4. XM_047416516.1 → XP_047272472.1  E3 ubiquitin-protein ligase UBR4 isoform X41

    5. XM_047416510.1 → XP_047272466.1  E3 ubiquitin-protein ligase UBR4 isoform X34

    6. XM_047416517.1 → XP_047272473.1  E3 ubiquitin-protein ligase UBR4 isoform X42

    7. XM_047416511.1 → XP_047272467.1  E3 ubiquitin-protein ligase UBR4 isoform X35

    8. XM_017000830.3 → XP_016856319.3  E3 ubiquitin-protein ligase UBR4 isoform X47

    9. XM_017000828.3 → XP_016856317.3  E3 ubiquitin-protein ligase UBR4 isoform X39

    10. XM_047416520.1 → XP_047272476.1  E3 ubiquitin-protein ligase UBR4 isoform X45

    11. XM_047416483.1 → XP_047272439.1  E3 ubiquitin-protein ligase UBR4 isoform X13

    12. XM_047416519.1 → XP_047272475.1  E3 ubiquitin-protein ligase UBR4 isoform X44

    13. XM_047416484.1 → XP_047272440.1  E3 ubiquitin-protein ligase UBR4 isoform X14

    14. XM_047416481.1 → XP_047272437.1  E3 ubiquitin-protein ligase UBR4 isoform X12

    15. XM_017000826.3 → XP_016856315.3  E3 ubiquitin-protein ligase UBR4 isoform X22

    16. XM_047416505.1 → XP_047272461.1  E3 ubiquitin-protein ligase UBR4 isoform X30

    17. XM_047416502.1 → XP_047272458.1  E3 ubiquitin-protein ligase UBR4 isoform X27

    18. XM_047416503.1 → XP_047272459.1  E3 ubiquitin-protein ligase UBR4 isoform X28

    19. XM_047416504.1 → XP_047272460.1  E3 ubiquitin-protein ligase UBR4 isoform X29

    20. XM_047416501.1 → XP_047272457.1  E3 ubiquitin-protein ligase UBR4 isoform X26

    21. XM_047416475.1 → XP_047272431.1  E3 ubiquitin-protein ligase UBR4 isoform X10

    22. XM_047416467.1 → XP_047272423.1  E3 ubiquitin-protein ligase UBR4 isoform X7

    23. XM_047416458.1 → XP_047272414.1  E3 ubiquitin-protein ligase UBR4 isoform X2

    24. XM_047416513.1 → XP_047272469.1  E3 ubiquitin-protein ligase UBR4 isoform X37

    25. XM_047416522.1 → XP_047272478.1  E3 ubiquitin-protein ligase UBR4 isoform X48

    26. XM_047416515.1 → XP_047272471.1  E3 ubiquitin-protein ligase UBR4 isoform X40

    27. XM_047416509.1 → XP_047272465.1  E3 ubiquitin-protein ligase UBR4 isoform X33

    28. XM_047416507.1 → XP_047272463.1  E3 ubiquitin-protein ligase UBR4 isoform X32

    29. XM_047416521.1 → XP_047272477.1  E3 ubiquitin-protein ligase UBR4 isoform X46

    30. XM_047416512.1 → XP_047272468.1  E3 ubiquitin-protein ligase UBR4 isoform X36

    31. XM_047416506.1 → XP_047272462.1  E3 ubiquitin-protein ligase UBR4 isoform X31

    32. XM_047416480.1 → XP_047272436.1  E3 ubiquitin-protein ligase UBR4 isoform X11

    33. XM_017000827.3 → XP_016856316.3  E3 ubiquitin-protein ligase UBR4 isoform X25

    34. XM_047416468.1 → XP_047272424.1  E3 ubiquitin-protein ligase UBR4 isoform X8

    35. XM_047416471.1 → XP_047272427.1  E3 ubiquitin-protein ligase UBR4 isoform X9

    36. XM_047416464.1 → XP_047272420.1  E3 ubiquitin-protein ligase UBR4 isoform X6

    37. XM_047416497.1 → XP_047272453.1  E3 ubiquitin-protein ligase UBR4 isoform X19

    38. XM_047416499.1 → XP_047272455.1  E3 ubiquitin-protein ligase UBR4 isoform X21

    39. XM_047416493.1 → XP_047272449.1  E3 ubiquitin-protein ligase UBR4 isoform X16

    40. XM_047416498.1 → XP_047272454.1  E3 ubiquitin-protein ligase UBR4 isoform X20

    41. XM_047416494.1 → XP_047272450.1  E3 ubiquitin-protein ligase UBR4 isoform X17

    42. XM_047416495.1 → XP_047272451.1  E3 ubiquitin-protein ligase UBR4 isoform X18

    43. XM_017000824.3 → XP_016856313.3  E3 ubiquitin-protein ligase UBR4 isoform X15

    44. XM_047416500.1 → XP_047272456.1  E3 ubiquitin-protein ligase UBR4 isoform X24

    45. XM_047416463.1 → XP_047272419.1  E3 ubiquitin-protein ligase UBR4 isoform X5

    46. XM_017000822.3 → XP_016856311.3  E3 ubiquitin-protein ligase UBR4 isoform X3

    47. XM_011541120.4 → XP_011539422.3  E3 ubiquitin-protein ligase UBR4 isoform X23

    48. XM_011541115.4 → XP_011539417.3  E3 ubiquitin-protein ligase UBR4 isoform X4

    49. XM_011541114.4 → XP_011539416.3  E3 ubiquitin-protein ligase UBR4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      18898062..19033778 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335600.1 → XP_054191575.1  E3 ubiquitin-protein ligase UBR4 isoform X43

    2. XM_054335595.1 → XP_054191570.1  E3 ubiquitin-protein ligase UBR4 isoform X38

    3. XM_054335606.1 → XP_054191581.1  E3 ubiquitin-protein ligase UBR4 isoform X49

    4. XM_054335598.1 → XP_054191573.1  E3 ubiquitin-protein ligase UBR4 isoform X41

    5. XM_054335591.1 → XP_054191566.1  E3 ubiquitin-protein ligase UBR4 isoform X34

    6. XM_054335599.1 → XP_054191574.1  E3 ubiquitin-protein ligase UBR4 isoform X42

    7. XM_054335592.1 → XP_054191567.1  E3 ubiquitin-protein ligase UBR4 isoform X35

    8. XM_054335604.1 → XP_054191579.1  E3 ubiquitin-protein ligase UBR4 isoform X47

    9. XM_054335596.1 → XP_054191571.1  E3 ubiquitin-protein ligase UBR4 isoform X39

    10. XM_054335602.1 → XP_054191577.1  E3 ubiquitin-protein ligase UBR4 isoform X45

    11. XM_054335570.1 → XP_054191545.1  E3 ubiquitin-protein ligase UBR4 isoform X13

    12. XM_054335601.1 → XP_054191576.1  E3 ubiquitin-protein ligase UBR4 isoform X44

    13. XM_054335571.1 → XP_054191546.1  E3 ubiquitin-protein ligase UBR4 isoform X14

    14. XM_054335569.1 → XP_054191544.1  E3 ubiquitin-protein ligase UBR4 isoform X12

    15. XM_054335579.1 → XP_054191554.1  E3 ubiquitin-protein ligase UBR4 isoform X22

    16. XM_054335587.1 → XP_054191562.1  E3 ubiquitin-protein ligase UBR4 isoform X30

    17. XM_054335584.1 → XP_054191559.1  E3 ubiquitin-protein ligase UBR4 isoform X27

    18. XM_054335585.1 → XP_054191560.1  E3 ubiquitin-protein ligase UBR4 isoform X28

    19. XM_054335586.1 → XP_054191561.1  E3 ubiquitin-protein ligase UBR4 isoform X29

    20. XM_054335583.1 → XP_054191558.1  E3 ubiquitin-protein ligase UBR4 isoform X26

    21. XM_054335567.1 → XP_054191542.1  E3 ubiquitin-protein ligase UBR4 isoform X10

    22. XM_054335564.1 → XP_054191539.1  E3 ubiquitin-protein ligase UBR4 isoform X7

    23. XM_054335559.1 → XP_054191534.1  E3 ubiquitin-protein ligase UBR4 isoform X2

    24. XM_054335594.1 → XP_054191569.1  E3 ubiquitin-protein ligase UBR4 isoform X37

    25. XM_054335605.1 → XP_054191580.1  E3 ubiquitin-protein ligase UBR4 isoform X48

    26. XM_054335597.1 → XP_054191572.1  E3 ubiquitin-protein ligase UBR4 isoform X40

    27. XM_054335590.1 → XP_054191565.1  E3 ubiquitin-protein ligase UBR4 isoform X33

    28. XM_054335589.1 → XP_054191564.1  E3 ubiquitin-protein ligase UBR4 isoform X32

    29. XM_054335603.1 → XP_054191578.1  E3 ubiquitin-protein ligase UBR4 isoform X46

    30. XM_054335593.1 → XP_054191568.1  E3 ubiquitin-protein ligase UBR4 isoform X36

    31. XM_054335588.1 → XP_054191563.1  E3 ubiquitin-protein ligase UBR4 isoform X31

    32. XM_054335568.1 → XP_054191543.1  E3 ubiquitin-protein ligase UBR4 isoform X11

    33. XM_054335582.1 → XP_054191557.1  E3 ubiquitin-protein ligase UBR4 isoform X25

    34. XM_054335565.1 → XP_054191540.1  E3 ubiquitin-protein ligase UBR4 isoform X8

    35. XM_054335566.1 → XP_054191541.1  E3 ubiquitin-protein ligase UBR4 isoform X9

    36. XM_054335563.1 → XP_054191538.1  E3 ubiquitin-protein ligase UBR4 isoform X6

    37. XM_054335576.1 → XP_054191551.1  E3 ubiquitin-protein ligase UBR4 isoform X19

    38. XM_054335578.1 → XP_054191553.1  E3 ubiquitin-protein ligase UBR4 isoform X21

    39. XM_054335573.1 → XP_054191548.1  E3 ubiquitin-protein ligase UBR4 isoform X16

    40. XM_054335577.1 → XP_054191552.1  E3 ubiquitin-protein ligase UBR4 isoform X20

    41. XM_054335574.1 → XP_054191549.1  E3 ubiquitin-protein ligase UBR4 isoform X17

    42. XM_054335575.1 → XP_054191550.1  E3 ubiquitin-protein ligase UBR4 isoform X18

    43. XM_054335572.1 → XP_054191547.1  E3 ubiquitin-protein ligase UBR4 isoform X15

    44. XM_054335581.1 → XP_054191556.1  E3 ubiquitin-protein ligase UBR4 isoform X24

    45. XM_054335562.1 → XP_054191537.1  E3 ubiquitin-protein ligase UBR4 isoform X5

    46. XM_054335560.1 → XP_054191535.1  E3 ubiquitin-protein ligase UBR4 isoform X3

    47. XM_054335580.1 → XP_054191555.1  E3 ubiquitin-protein ligase UBR4 isoform X23

    48. XM_054335561.1 → XP_054191536.1  E3 ubiquitin-protein ligase UBR4 isoform X4

    49. XM_054335558.1 → XP_054191533.1  E3 ubiquitin-protein ligase UBR4 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5T4S7.1 GenPept UniProtKB/Swiss-Prot:Q5T4S7

    Gene LinkOut

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