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    AGR3 anterior gradient 3, protein disulphide isomerase family member [ Homo sapiens (human) ]

    Gene ID: 155465, updated on 27-Nov-2024

    Summary

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    Official Symbol
    AGR3provided by HGNC
    Official Full Name
    anterior gradient 3, protein disulphide isomerase family memberprovided by HGNC
    Primary source
    HGNC:HGNC:24167
    See related
    Ensembl:ENSG00000173467 MIM:609482; AllianceGenome:HGNC:24167
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AG3; AG-3; HAG3; hAG-3; BCMP11; PDIA18
    Summary
    This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This gene is expressed in ciliated airway epithelial cells and, in mouse, plays a role in ciliary beat frequency in multiciliated cells. This gene is also over-expressed in breast, ovarian, and prostrate cancers. [provided by RefSeq, Dec 2016]
    Expression
    Biased expression in small intestine (RPKM 65.6), colon (RPKM 63.5) and 4 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See AGR3 in Genome Data Viewer
    Location:
    7p21.1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (16854681..16881983, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (16984265..17011519, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (16899036..16921607, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene anterior gradient 2, protein disulphide isomerase family member Neighboring gene Rho GTPase activating protein 20 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:16902535-16902704 Neighboring gene RAD17 pseudogene 1 Neighboring gene LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) pseudogene Neighboring gene Sharpr-MPRA regulatory region 11479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:16982305-16982806 Neighboring gene uncharacterized LOC124901594

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The anterior gradient homolog 3 (AGR3) gene is associated with differentiation and survival in ovarian cancer. King ER, et al. Am J Surg Pathol, 2011 Jun. PMID 21451362, Free PMC Article
    2. Over-expression of Anterior Gradient 3 Is Associated With Tumor Progression and Poor Survival in Gastric Cancer. Lee WS, et al. In Vivo, 2023 Jan-Feb. PMID 36593009, Free PMC Article
    3. Anterior Gradient-3: a novel biomarker for ovarian cancer that mediates cisplatin resistance in xenograft models. Gray TA, et al. J Immunol Methods, 2012 Apr 30. PMID 22361111
    4. Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer. Jiang R, et al. Breast Cancer Res Treat, 2021 Nov. PMID 34519905
    5. Profile of anterior gradient 3 (AGR3) mRNA expression and serum levels in benign and malignant breast tumors. Prihantono P, et al. Breast Dis, 2021. PMID 34057117

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis.
      Title: Prognostic Impact of AGR3 Protein Expression in Breast Cancer: A Systematic Review and Meta-analysis.
    2. Over-expression of Anterior Gradient 3 Is Associated With Tumor Progression and Poor Survival in Gastric Cancer.
      Title: Over-expression of Anterior Gradient 3 Is Associated With Tumor Progression and Poor Survival in Gastric Cancer.
    3. Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.
      Title: Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer.
    4. Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer.
      Title: Estrogen-regulated AGR3 activates the estrogen receptor signaling pathway to promote tamoxifen resistance in breast cancer.
    5. Profile of anterior gradient 3 (AGR3) mRNA expression and serum levels in benign and malignant breast tumors.
      Title: Profile of anterior gradient 3 (AGR3) mRNA expression and serum levels in benign and malignant breast tumors.
    6. Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure.
      Title: Anterior Gradient Protein 3 and S100 Calcium-Binding Protein P Levels in Different Endometrial Epithelial Compartments May Play an Important Role in Recurrent Pregnancy Failure.
    7. AGR3 promotes the stemness of colorectal cancer via modulating Wnt/beta-catenin signalling.
      Title: AGR3 promotes the stemness of colorectal cancer via modulating Wnt/β-catenin signalling.
    8. The recombinant expression, purification, crystallization and structure of the human AGR3 are described.
      Title: Crystal structure of human anterior gradient protein 3.
    9. Results show that AGR3 was highly upregulated in low-grade serous carcinoma (LGSC) compared to high-grade serous carcinoma (HGSC). It can be use along with p53 for differential diagnosis of HGSC and LGSC.
      Title: Combination of TP53 and AGR3 to distinguish ovarian high-grade serous carcinoma from low-grade serous carcinoma.
    10. transcriptionally activated in hepatitis C virus-infected cells by HCV NS5A
      Title: The NS5A protein of hepatitis C virus transcriptionally upregulates the AGR3 gene expression.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Exploring genome-wide - dietary heme iron intake interactions and the risk of type 2 diabetes.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables dystroglycan binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dystroglycan binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		  
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
    		  

    General protein information

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    Preferred Names
    anterior gradient protein 3
    Names
    anterior gradient homolog 3
    anterior gradient protein 3 homolog
    breast cancer membrane protein 11
    protein disulfide isomerase family A, member 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_176813.5 → NP_789783.1  anterior gradient protein 3 precursor

      See identical proteins and their annotated locations for NP_789783.1

      Status: VALIDATED

      Source sequence(s)
      BC058284, BU682778
      Consensus CDS
      CCDS5365.1
      UniProtKB/Swiss-Prot
      A4D120, Q8TD06
      UniProtKB/TrEMBL
      B5MC62
      Related
      ENSP00000308606.2, ENST00000310398.7
      Conserved Domains (1) summary
      cd02960
      Location:37 → 166
      AGR; Anterior Gradient (AGR) family; members of this family are similar to secreted proteins encoded by the cement gland-specific genes XAG-1 and XAG-2, expressed in the anterior region of dorsal ectoderm of Xenopus. They are implicated in the formation of ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      16854681..16881983 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011515152.3 → XP_011513454.1  anterior gradient protein 3 isoform X2

      See identical proteins and their annotated locations for XP_011513454.1

      UniProtKB/TrEMBL
      B5MC62
      Related
      ENSP00000386016.3, ENST00000402239.7
      Conserved Domains (1) summary
      cl00388
      Location:37 → 150
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

    2. XM_047419928.1 → XP_047275884.1  anterior gradient protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A4D120, Q8TD06

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      16984265..17011519 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357364.1 → XP_054213339.1  anterior gradient protein 3 isoform X2

    2. XM_054357363.1 → XP_054213338.1  anterior gradient protein 3 isoform X1

      UniProtKB/Swiss-Prot
      A4D120, Q8TD06
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TD06.1 GenPept UniProtKB/Swiss-Prot:Q8TD06

    Gene LinkOut

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