U.S. flag

An official website of the United States government

Links from Protein

    • Showing Current items.

    Rrp46 Rrp46 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41270, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rrp46provided by FlyBase
    Official Full Name
    Rrp46provided by FlyBase
    Primary source
    FLYBASE:FBgn0037815
    Locus tag
    Dmel_CG4043
    See related
    AllianceGenome:FB:FBgn0037815
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4043; Dmel\CG4043; dRrp46; rrp46
    Summary
    Predicted to enable RNA binding activity. Involved in regulation of gene expression. Located in cytoplasm. Part of nuclear exosome (RNase complex). Orthologous to human EXOSC5 (exosome component 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rrp46 in Genome Data Viewer
    Location:
    86B4-86B4; 3-49 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (10413301..10414242)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (6239023..6239964)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene mir-318 stem loop Neighboring gene Iron regulatory protein 1B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytochrome P450 12e1

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding  
    Process Evidence Code Pubs
    involved_in U4 snRNA 3'-end processing  
    involved_in nuclear mRNA surveillance  
    involved_in poly(A)-dependent snoRNA 3'-end processing  
    involved_in rRNA catabolic process  
    involved_in regulation of gene expression PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm PubMed 
    part_of cytoplasmic exosome (RNase complex)  
    part_of exosome (RNase complex) PubMed 
    part_of nuclear exosome (RNase complex)  
    part_of nuclear exosome (RNase complex) PubMed 
    part_of nuclear exosome (RNase complex) PubMed 
    is_active_in nucleolus  

    General protein information

    Preferred Names
    Rrp46
    Names
    CG4043-PA
    Rrp46-PA

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      10413301..10414242
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141744.3 → NP_650001.2  Rrp46 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650001.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TW1, Q9VGZ2
      Related
      FBpp0081725
      Conserved Domains (2) summary
      cd11372
      Location:14 → 211
      RNase_PH_RRP46; RRP46 subunit of eukaryotic exosome
      COG0689
      Location:10 → 215
      Rph; Ribonuclease PH [Translation, ribosomal structure and biogenesis]
    External link. Please review our privacy policy.