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    Mgtor Megator [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36264, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mgtorprovided by FlyBase
    Official Full Name
    Megatorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0013756
    Locus tag
    Dmel_CG8274
    See related
    AllianceGenome:FB:FBgn0013756
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Bx34; CG8274; Dmel\CG8274; l(2)k03905; mtor; Mtor; MTOR; Tpr; TPR
    Summary
    Enables chromatin DNA binding activity and histone acetyltransferase binding activity. Involved in several processes, including regulation of gene expression; regulation of mitotic nuclear division; and spindle organization. Located in several cellular components, including euchromatin; nucleus; and spindle. Part of nuclear pore. Is expressed in adult brain cell body rind; adult head; adult optic lobe; male germline cell; and somatic cell of testis. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder. Orthologous to human TPR (translocated promoter region, nuclear basket protein). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Mgtor in Genome Data Viewer
    Location:
    48C5-48C5; 2-65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (11852617..11861202)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7740122..7748707)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR44304 Neighboring gene uncharacterized protein Neighboring gene Silnoon Neighboring gene uncharacterized protein Neighboring gene Tweedlebeta

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables chromatin DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonucleoprotein complex binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables structural constituent of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in chromatin organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in chromatin remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in germ-line stem-cell niche homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in male germ-line stem cell asymmetric division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle assembly checkpoint signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of intracellular protein transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of chromosome segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of metaphase plate congression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic sister chromatid separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of mitotic spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in regulation of mitotic spindle elongation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of mitotic spindle organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to endoplasmic reticulum stress HMP PubMed 
    involved_in response to heat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in sex-chromosome dosage compensation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spindle assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in euchromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in metaphase plate IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope HDA PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear inclusion body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear lamina IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of nuclear pore IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm HDA PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle midzone IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    megator
    Names
    CG8274-PA
    CG8274-PB
    Mgtor-PA
    Mgtor-PB
    lethal (2) k03905

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      11852617..11861202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273974.1NP_001260903.1  megator, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260903.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z8P9, O01385
      UniProtKB/TrEMBL
      A0A0B4KFE9
      Conserved Domains (5) summary
      cd00187
      Location:13981605
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      TIGR04523
      Location:177911
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam07926
      Location:10311158
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam09728
      Location:12011476
      Taxilin; Myosin-like coiled-coil protein
      pfam13863
      Location:833915
      DUF4200; Domain of unknown function (DUF4200)
    2. NM_057719.4NP_477067.2  megator, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477067.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1Z8P9, O01385
      UniProtKB/TrEMBL
      A0A0B4KFE9
      Related
      FBpp0087140
      Conserved Domains (5) summary
      cd00187
      Location:13981605
      TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
      TIGR04523
      Location:177911
      Mplasa_alph_rch; helix-rich Mycoplasma protein
      pfam07926
      Location:10311158
      TPR_MLP1_2; TPR/MLP1/MLP2-like protein
      pfam09728
      Location:12011476
      Taxilin; Myosin-like coiled-coil protein
      pfam13863
      Location:833915
      DUF4200; Domain of unknown function (DUF4200)