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    Tgi Tondu-domain-containing Growth Inhibitor [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tgiprovided by FlyBase
    Official Full Name
    Tondu-domain-containing Growth Inhibitorprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036373
    Locus tag
    Dmel_CG10741
    See related
    AllianceGenome:FB:FBgn0036373
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10741; Dmel\CG10741; NEST:bs23g10; SdBP; tgi
    Summary
    Enables DNA-binding transcription factor binding activity and transcription coactivator binding activity. Involved in negative regulation of DNA-templated transcription. Located in nucleus. Orthologous to human VGLL4 (vestigial like family member 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tgi in Genome Data Viewer
    Location:
    70B2-70B3; 3-40 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13486797..13502492)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13479897..13495592)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene starvin Neighboring gene Actin binding protein 1 Neighboring gene Spt20 Neighboring gene Vacuolar protein sorting 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential Binding Affinities and Allosteric Conformational Changes Underlie Interactions of Yorkie and a Multivalent PPxY Partner. Nyarko A. Biochemistry, 2018 Feb 6. PMID 29257682
    2. From vestigial to vestigial-like: the Drosophila gene that has taken wing. Simon E, et al. Dev Genes Evol, 2016 Jul. PMID 27116603
    3. A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis. Shen S, et al. Cell Res, 2015 Sep. PMID 26272168, Free PMC Article
    4. The Drosophila Hippo pathway transcription factor Scalloped and its co-factors alter each other's chromatin binding dynamics and transcription in vivo. Manning SA, et al. Dev Cell, 2024 Jul 8. PMID 38670104
    5. The role of lysine palmitoylation/myristoylation in the function of the TEAD transcription factors. Mesrouze Y, et al. Sci Rep, 2022 Mar 23. PMID 35322151, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications.
      Title: Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications.
    2. Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi.
      Title: Pits and CtBP Control Tissue Growth in Drosophila melanogaster with the Hippo Pathway Transcription Repressor Tgi.
    3. This study presents successfully overexpressed full length recombinant Tgi and Yki, experimentally confirms that intrinsic structural disorder is common to both proteins, and assesses binding of the Yki WW domains to the three Tgi PPxY motifs using nuclear magnetic resonance and isothermal titration calorimetry.
      Title: Differential Binding Affinities and Allosteric Conformational Changes Underlie Interactions of Yorkie and a Multivalent PPxY Partner.
    4. This study identifies a novel protein Sd-Binding-Protein (SdBP)/Tgi, which directly competes with Yki for binding to Sd through its TDU domains and inhibits the Sd-Yki transcriptional activity.
      Title: A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tondu-domain-containing growth inhibitor
    Names
    CG10741-PA
    CG10741-PB
    Sd-Binding-Protein
    Tgi-PA
    Tgi-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      13486797..13502492
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140401.2 → NP_648658.1  Tondu-domain-containing growth inhibitor, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648658.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IQJ9
      Related
      FBpp0075552
      Conserved Domains (2) summary
      smart00711
      Location:129 → 144
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:105 → 144
      VGLL4; Transcription cofactor vestigial-like protein 4

    2. NM_168555.2 → NP_729916.1  Tondu-domain-containing growth inhibitor, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729916.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VU85
      Related
      FBpp0075553
      Conserved Domains (2) summary
      smart00711
      Location:282 → 297
      TDU; Short repeats in human TONDU, fly vestigial and other proteins
      pfam15245
      Location:258 → 297
      VGLL4; Transcription cofactor vestigial-like protein 4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQJ9 Q8IQJ9
    Q9VU85 Q9VU85

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