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    Ice2 interactor of little elongation complex ELL subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 93697, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ice2provided by MGI
    Official Full Name
    interactor of little elongation complex ELL subunit 2provided by MGI
    Primary source
    MGI:MGI:2135947
    See related
    Ensembl:ENSMUSG00000032235 AllianceGenome:MGI:2135947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Narg2; B230343B06Rik
    Summary
    Predicted to be involved in positive regulation of transcription by RNA polymerase III; snRNA transcription by RNA polymerase II; and snRNA transcription by RNA polymerase III. Located in nucleus. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human ICE2 (interactor of little elongation complex ELL subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 3.9), limb E14.5 (RPKM 3.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ice2 in Genome Data Viewer
    Location:
    9 C; 9 38.58 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (69305185..69340360)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (69397904..69433078)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RAR-related orphan receptor alpha Neighboring gene predicted gene, 46153 Neighboring gene predicted gene 15511 Neighboring gene STARR-seq mESC enhancer starr_24519 Neighboring gene purine-nucleoside phosphorylase pseudogene Neighboring gene predicted gene 7802

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Murine equivalent of the human histo-blood group ABO gene is a cis-AB gene and encodes a glycosyltransferase with both A and B transferase activity. Yamamoto M, et al. J Biol Chem, 2001 Apr 27. PMID 11278752
    2. NARG2 encodes a novel nuclear protein with (S/T)PXX motifs that is expressed during development. Sugiura N, et al. Eur J Biochem, 2004 Dec. PMID 15606750
    3. N-methyl-D-aspartate receptors regulate a group of transiently expressed genes in the developing brain. Sugiura N, et al. J Biol Chem, 2001 Apr 27. PMID 11297529
    4. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    5. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in snRNA transcription by RNA polymerase III ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Cajal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Cajal body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in euchromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in histone locus body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in histone locus body ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription elongation factor complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription elongation factor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    little elongation complex subunit 2
    Names
    NMDA receptor-regulated gene 2
    NMDA receptor-regulated protein 2
    interactor of little elongator complex ELL subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145618.3 → NP_663593.2  little elongation complex subunit 2

      See identical proteins and their annotated locations for NP_663593.2

      Status: VALIDATED

      Source sequence(s)
      BC068183
      Consensus CDS
      CCDS23315.1
      UniProtKB/Swiss-Prot
      B0V2P1, Q3UZ18, Q66JS8, Q7TNL8, Q8BQZ1, Q8VEI2
      Related
      ENSMUSP00000034761.9, ENSMUST00000034761.15
      Conserved Domains (2) summary
      PHA03247
      Location:429 → 473
      PHA03247; large tegument protein UL36; Provisional
      pfam10505
      Location:728 → 936
      NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      69305185..69340360
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155420.1 → XP_036011313.1  little elongation complex subunit 2 isoform X1

      UniProtKB/Swiss-Prot
      B0V2P1, Q3UZ18, Q66JS8, Q7TNL8, Q8BQZ1, Q8VEI2
      Conserved Domains (2) summary
      PHA03247
      Location:429 → 473
      PHA03247; large tegument protein UL36; Provisional
      pfam10505
      Location:728 → 936
      NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

    2. XM_006511573.5 → XP_006511636.1  little elongation complex subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_006511636.1

      UniProtKB/Swiss-Prot
      B0V2P1, Q3UZ18, Q66JS8, Q7TNL8, Q8BQZ1, Q8VEI2
      Conserved Domains (2) summary
      PHA03247
      Location:429 → 473
      PHA03247; large tegument protein UL36; Provisional
      pfam10505
      Location:728 → 936
      NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

    3. XM_006511575.5 → XP_006511638.1  little elongation complex subunit 2 isoform X3

      Conserved Domains (2) summary
      PHA03247
      Location:296 → 340
      PHA03247; large tegument protein UL36; Provisional
      pfam10505
      Location:595 → 803
      NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

    4. XM_006511574.5 → XP_006511637.1  little elongation complex subunit 2 isoform X2

      Conserved Domains (2) summary
      PHA03247
      Location:394 → 438
      PHA03247; large tegument protein UL36; Provisional
      pfam10505
      Location:693 → 901
      NARG2_C; NMDA receptor-regulated gene protein 2 C-terminus

    RNA

    1. XR_004935620.1 RNA Sequence

    2. XR_004935618.1 RNA Sequence

    3. XR_004935619.1 RNA Sequence

    4. XR_379471.4 RNA Sequence

    5. XR_004935621.1 RNA Sequence

    6. XR_003948073.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UZ18.2 GenPept UniProtKB/Swiss-Prot:Q3UZ18

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