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    NKAIN Na,K-ATPase Interacting [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NKAINprovided by FlyBase
    Official Full Name
    Na,K-ATPase Interactingprovided by FlyBase
    Primary source
    FLYBASE:FBgn0085442
    Locus tag
    Dmel_CG34413
    See related
    AllianceGenome:FB:FBgn0085442
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.94; CG32836; CG34413; CG9047; Dmel\CG34413; dNKAIN
    Old locus tag
    CG32836; CG9047; Dmel_CG32836; Dmel_CG9047
    Summary
    Involved in regulation of sodium ion transport. Is expressed in several structures, including adult brain; adult head; anterior endoderm; embryonic/larval midgut; and embryonic/larval midgut primordium. Orthologous to several human genes including NKAIN1 (sodium/potassium transporting ATPase interacting 1); NKAIN2 (sodium/potassium transporting ATPase interacting 2); and NKAIN3 (sodium/potassium transporting ATPase interacting 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See NKAIN in Genome Data Viewer
    Location:
    60E5-60E5; 2-107 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24881570..24888615)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20769093..20776138)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43466 Neighboring gene Ance-5 Neighboring gene Na channel protein 60E Neighboring gene uncharacterized protein Neighboring gene Thiamine pyrophosphate carrier protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A novel family of transmembrane proteins interacting with beta subunits of the Na,K-ATPase. Gorokhova S, et al. Hum Mol Genet, 2007 Oct 15. PMID 17606467
    2. Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency. Walker JA, et al. PLoS Genet, 2013 Nov. PMID 24278035, Free PMC Article
    3. A genetic toolkit for tagging intronic MiMIC containing genes. Nagarkar-Jaiswal S, et al. Elife, 2015 Jun 23. PMID 26102525, Free PMC Article
    4. Drosophila glia: Few cell types and many conserved functions. Yildirim K, et al. Glia, 2019 Jan. PMID 30443934
    5. A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity. Baumbach J, et al. Cell Metab, 2014 Feb 4. PMID 24506874

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of sodium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of sodium ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    Na,K-ATPase interacting
    Names
    CG34413-PF
    CG34413-PG
    CG34413-PH
    CG34413-PI
    CG34413-PJ
    CG34413-PK
    CG34413-PL
    NKAIN-PF
    NKAIN-PG
    NKAIN-PH
    NKAIN-PI
    NKAIN-PJ
    NKAIN-PK
    NKAIN-PL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      24881570..24888615
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001299931.1 → NP_001286860.1  Na,K-ATPase interacting, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286860.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4LGJ7, B9EQX8
      Conserved Domains (1) summary
      pfam05640
      Location:12 → 196
      NKAIN; Na,K-Atpase Interacting protein

    2. NM_001103979.4 → NP_001097449.2  Na,K-ATPase interacting, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097449.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BN4
      Conserved Domains (1) summary
      pfam05640
      Location:12 → 181
      NKAIN; Na,K-Atpase Interacting protein

    3. NM_166694.3 → NP_726493.2  Na,K-ATPase interacting, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726493.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6MHQ4, Q8MMC8, Q961Q4
      UniProtKB/TrEMBL
      B5RJJ9, D2NUK1
      Conserved Domains (1) summary
      pfam05640
      Location:12 → 199
      NKAIN; Na,K-Atpase Interacting protein

    4. NM_166693.3 → NP_726492.2  Na,K-ATPase interacting, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726492.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6MHQ4, Q8MMC8, Q961Q4
      UniProtKB/TrEMBL
      B5RJJ9, D2NUK1
      Conserved Domains (1) summary
      pfam05640
      Location:12 → 199
      NKAIN; Na,K-Atpase Interacting protein

    5. NM_138131.4 → NP_611975.3  Na,K-ATPase interacting, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611975.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6MHQ4, Q8MMC8, Q961Q4
      UniProtKB/TrEMBL
      B5RJJ9, D2NUK1
      Conserved Domains (1) summary
      pfam05640
      Location:12 → 199
      NKAIN; Na,K-Atpase Interacting protein

    6. NM_001169826.3 → NP_001163297.1  Na,K-ATPase interacting, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163297.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B9EQX8, E1JGW7
      Conserved Domains (1) summary
      pfam05640
      Location:12 → 177
      NKAIN; Na,K-Atpase Interacting protein

    7. NM_001259577.2 → NP_001246506.1  Na,K-ATPase interacting, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246506.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6MHQ4, Q8MMC8, Q961Q4
      UniProtKB/TrEMBL
      B5RJJ9, D2NUK1
      Conserved Domains (1) summary
      pfam05640
      Location:12 → 199
      NKAIN; Na,K-Atpase Interacting protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4LGJ7 A0A0B4LGJ7
    A6MHQ4.1 A6MHQ4
    B5RJJ9 B5RJJ9
    E1JGW7 E1JGW7
    Q86BN4 Q86BN4

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