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    Rad60 Rad60 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42748, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rad60provided by FlyBase
    Official Full Name
    Rad60provided by FlyBase
    Primary source
    FLYBASE:FBgn0039065
    Locus tag
    Dmel_CG4449
    See related
    AllianceGenome:FB:FBgn0039065
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG4449; Dmel\CG4449; drad60; dRad60; RENi
    Summary
    Involved in double-strand break repair via homologous recombination. Located in nuclear periphery. Is expressed in central brain primordium; embryonic brain; larval ventral nerve cord; organism; and ventral nerve cord primordium. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rad60 in Genome Data Viewer
    Location:
    94E8-94E9; 3-78 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (23249443..23251477, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (19075165..19077199, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene cap-n-collar Neighboring gene fuzzy onions Neighboring gene uncharacterized protein Neighboring gene Elongin A Neighboring gene will decrease acetylation Neighboring gene Peroxin 11c

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. NetREX-CF integrates incomplete transcription factor data with gene expression to reconstruct gene regulatory networks. Wang Y, et al. Commun Biol, 2022 Nov 23. PMID 36418514, Free PMC Article
    2. And yet, it moves: nuclear and chromatin dynamics of a heterochromatic double-strand break. Caridi PC, et al. Philos Trans R Soc Lond B Biol Sci, 2017 Oct 5. PMID 28847828, Free PMC Article
    3. Nuclear Dynamics of Heterochromatin Repair. Amaral N, et al. Trends Genet, 2017 Feb. PMID 28104289, Free PMC Article
    4. The Ski2-family helicase Obelus regulates Crumbs alternative splicing and cell polarity. Vichas A, et al. J Cell Biol, 2015 Dec 7. PMID 26644515, Free PMC Article
    5. Heterochromatic breaks move to the nuclear periphery to continue recombinational repair. Ryu T, et al. Nat Cell Biol, 2015 Nov. PMID 26502056, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Rad60
    Names
    CG4449-PA
    CG4449-PB
    CG4449-PC
    CG4449-PD
    CG4449-PE
    CG4449-PF
    Rad60-PA
    Rad60-PB
    Rad60-PC
    Rad60-PD
    Rad60-PE
    Rad60-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      23249443..23251477 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170227.1 → NP_001163698.1  Rad60, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163698.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIU3, E4NKN5
      Conserved Domains (1) summary
      cl00155
      Location:390 → 420
      UBQ; Ubiquitin-like proteins

    2. NM_142877.1 → NP_651134.1  Rad60, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651134.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSB4, Q9VCP1
      UniProtKB/TrEMBL
      E4NKN5, H0RNC3
      Related
      FBpp0083780, FBtr0084388
      Conserved Domains (1) summary
      cl00155
      Location:392 → 422
      UBQ; Ubiquitin-like proteins

    3. NM_001275940.1 → NP_001262869.1  Rad60, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262869.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHP8, E4NKN5
      Conserved Domains (1) summary
      cl00155
      Location:389 → 419
      UBQ; Ubiquitin-like proteins

    4. NM_001275937.1 → NP_001262866.1  Rad60, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E1JIU3, E4NKN5
      Conserved Domains (1) summary
      cl00155
      Location:390 → 420
      UBQ; Ubiquitin-like proteins

    5. NM_001275939.1 → NP_001262868.1  Rad60, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262868.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KHY5, E4NKN5
      Conserved Domains (1) summary
      cl00155
      Location:391 → 421
      UBQ; Ubiquitin-like proteins

    6. NM_001275938.1 → NP_001262867.1  Rad60, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262867.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8MSB4, Q9VCP1
      UniProtKB/TrEMBL
      E4NKN5, H0RNC3
      Conserved Domains (1) summary
      cl00155
      Location:392 → 422
      UBQ; Ubiquitin-like proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KHP8 A0A0B4KHP8
    A0A0B4KHY5 A0A0B4KHY5
    E1JIU3 E1JIU3
    H0RNC3 H0RNC3
    Q9VCP1.4 Q9VCP1

    Gene LinkOut

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