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    wds will die slowly [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 53428, updated on 17-Dec-2024

    Summary

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    Official Symbol
    wdsprovided by FlyBase
    Official Full Name
    will die slowlyprovided by FlyBase
    Primary source
    FLYBASE:FBgn0040066
    Locus tag
    Dmel_CG17437
    See related
    AllianceGenome:FB:FBgn0040066
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17437; Dmel\CG17437; dWds; EG:BACR25B3.7; l(1)16-94; l(1)3Ad; l(1)G0251; l(1)zw8; WD5; WDR5; Wds; WDS; zw-8; zw8
    Summary
    Predicted to enable histone binding activity. Involved in several processes, including chromatin remodeling; haltere development; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in nucleus. Part of histone acetyltransferase complex and histone methyltransferase complex. Is expressed in several structures, including adult head; dorsal pharyngeal muscle cell; ganglia; gut section; and larval muscle system. Used to study congenital heart disease. Orthologous to several human genes including WDR5 (WD repeat domain 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See wds in Genome Data Viewer
    Location:
    3A6-3A6; 1-1 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (2585980..2588217)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (2480013..2482250)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Vacuolar H[+] ATPase 36kD subunit 3 Neighboring gene Arylalkylamine N-acetyltransferase-like 7 Neighboring gene uncharacterized protein Neighboring gene egghead Neighboring gene Kinesin-like protein at 3A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A genetic screen in Drosophila implicates Sex comb on midleg (Scm) in tissue overgrowth and mechanisms of Scm degradation by Wds. Guo J, et al. Mech Dev, 2015 May. PMID 25772304
    2. Active N(6)-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons. Yao B, et al. Mol Cell, 2018 Sep 6. PMID 30078725, Free PMC Article
    3. A clustering of heterozygous missense variants in the crucial chromatin modifier WDR5 defines a new neurodevelopmental disorder. Snijders Blok L, et al. HGG Adv, 2023 Jan 12. PMID 36408368, Free PMC Article
    4. The opportunities and challenges of using Drosophila to model human cardiac diseases. Zhao Y, et al. Front Physiol, 2023. PMID 37123266, Free PMC Article
    5. The essential Drosophila melanogaster gene wds (will die slowly) codes for a WD-repeat protein with seven repeats. Hollmann M, et al. Mol Genet Genomics, 2002 Dec. PMID 12471440

    See all (130) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A clustering of heterozygous missense variants in the crucial chromatin modifier WDR5 defines a new neurodevelopmental disorder.
      Title: A clustering of heterozygous missense variants in the crucial chromatin modifier WDR5 defines a new neurodevelopmental disorder.
    2. Wds promotes Scm degradation through ubiquitination in vitro in Drosophila.
      Title: A genetic screen in Drosophila implicates Sex comb on midleg (Scm) in tissue overgrowth and mechanisms of Scm degradation by Wds.
    3. The essential Drosophila melanogaster gene wds (will die slowly) codes for a WD-repeat protein with seven repeats.
      Title: The essential Drosophila melanogaster gene wds (will die slowly) codes for a WD-repeat protein with seven repeats.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in eye development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in haltere development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in haltere development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in heart development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ATAC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ATAC complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of MLL1/2 complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    part_of MLL3/4 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of NSL complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    will die slowly
    Names
    CG17437-PA
    CG17437-PB
    lethal(1)3Ad
    wds-PA
    wds-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      2585980..2588217
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258574.2 → NP_001245503.1  will die slowly, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245503.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3J8
      UniProtKB/TrEMBL
      M9NDM4
      Conserved Domains (2) summary
      cd00200
      Location:64 → 358
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:75 → 112
      7WD40; WD40 repeat [structural motif]

    2. NM_080245.5 → NP_524984.1  will die slowly, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524984.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9V3J8
      UniProtKB/TrEMBL
      M9NDM4
      Related
      FBpp0070422
      Conserved Domains (2) summary
      cd00200
      Location:64 → 358
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:75 → 112
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9NDM4 M9NDM4
    Q9V3J8.1 Q9V3J8

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