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    Rpp25 Ribonuclease P/MRP subunit p25 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 35574, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rpp25provided by FlyBase
    Official Full Name
    Ribonuclease P/MRP subunit p25provided by FlyBase
    Primary source
    FLYBASE:FBgn0033092
    Locus tag
    Dmel_CG9422
    See related
    AllianceGenome:FB:FBgn0033092
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:RE35072; CG9422; Dmel\CG9422; Pop6
    Summary
    Predicted to enable ribonuclease P RNA binding activity. Predicted to be involved in tRNA 5'-leader removal. Predicted to be part of multimeric ribonuclease P complex and ribonuclease MRP complex. Orthologous to human RPP25 (ribonuclease P and MRP subunit p25) and RPP25L (ribonuclease P/MRP subunit p25 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Rpp25 in Genome Data Viewer
    Location:
    42C4-42C5; 2-55 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (6675822..6693162)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (2563327..2580667)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Heparan sulfate C5-epimerase Neighboring gene Post-GPI attachment to proteins 3 Neighboring gene uncharacterized protein Neighboring gene Tyrosine decarboxylase 1 Neighboring gene long non-coding RNA:CR44164 Neighboring gene antisense RNA:CR44165 Neighboring gene uncharacterized protein Neighboring gene Tyrosine decarboxylase 2 Neighboring gene uncharacterized protein Neighboring gene MOB kinase activator 4 Neighboring gene Rab2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Biogenesis of RNase P RNA from an intron requires co-assembly with cognate protein subunits. Palsule G, et al. Nucleic Acids Res, 2019 Sep 19. PMID 31287870, Free PMC Article
    2. Bap170, a subunit of the Drosophila PBAP chromatin remodeling complex, negatively regulates the EGFR signaling. Rendina R, et al. Genetics, 2010 Sep. PMID 20551433, Free PMC Article
    3. Inventory and analysis of the protein subunits of the ribonucleases P and MRP provides further evidence of homology between the yeast and human enzymes. Rosenblad MA, et al. Nucleic Acids Res, 2006. PMID 16998185, Free PMC Article
    4. Transcriptional response to dietary restriction in Drosophila melanogaster. Ding F, et al. J Insect Physiol, 2014 Oct. PMID 24819200, Free PMC Article
    5. Modularity and hormone sensitivity of the Drosophila melanogaster insulin receptor/target of rapamycin interaction proteome. Glatter T, et al. Mol Syst Biol, 2011 Nov 8. PMID 22068330, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonuclease P RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA 5'-leader removal IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA 5'-leader removal ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of multimeric ribonuclease P complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of ribonuclease MRP complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonuclease MRP complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    ribonuclease P/MRP subunit p25
    Names
    CG9422-PA
    CG9422-PC
    CG9422-PD
    Rpp25-PA
    Rpp25-PC
    Rpp25-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      6675822..6693162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136383.4 → NP_610227.2  ribonuclease P/MRP subunit p25, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610227.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9N4, Q6NNC7
      Related
      FBpp0085455
      Conserved Domains (1) summary
      pfam01918
      Location:34 → 97
      Alba; Alba

    2. NM_165484.3 → NP_724490.1  ribonuclease P/MRP subunit p25, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724490.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9N4, Q6NNC7
      Related
      FBpp0085454
      Conserved Domains (1) summary
      pfam01918
      Location:34 → 97
      Alba; Alba

    3. NM_001259221.2 → NP_001246150.1  ribonuclease P/MRP subunit p25, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246150.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E9N4, Q6NNC7
      Conserved Domains (1) summary
      pfam01918
      Location:34 → 97
      Alba; Alba
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E9N4 Q0E9N4
    Q8SXI3 Q8SXI3

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