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    pde-1 Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-1 [ Caenorhabditis elegans ]

    Gene ID: 173200, updated on 9-Dec-2024

    Summary

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    Official Symbol
    pde-1
    Official Full Name
    Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-1
    Primary source
    WormBase:WBGene00011433
    Locus tag
    CELE_T04D3.3
    See related
    AllianceGenome:WB:WBGene00011433
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin binding activity. Involved in several processes, including determination of adult lifespan; negative regulation of intracellular signal transduction; and response to hydrogen peroxide. Is expressed in head and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to several human genes including PDE1A (phosphodiesterase 1A) and PDE1B (phosphodiesterase 1B). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See pde-1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    12
    Sequence:
    Chromosome: I; NC_003279.8 (13310887..13318716, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene SKN-1 Dependent Zygotic transcript Neighboring gene Uncharacterized protein Neighboring gene tRNA-Thr Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene tRNA-Gly

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Altering Neuropeptide Expression. Beets I, et al. Neuron, 2020 Jan 8. PMID 31757604, Free PMC Article
    2. Control of Neuropeptide Expression by Parallel Activity-dependent Pathways in Caenorhabditis elegans. Rojo Romanos T, et al. Sci Rep, 2017 Jan 31. PMID 28139692, Free PMC Article
    3. cGMP dynamics that underlies thermosensation in temperature-sensing neuron regulates thermotaxis behavior in C. elegans. Aoki I, et al. PLoS One, 2022. PMID 36472979, Free PMC Article
    4. GCY-8, PDE-2, and NCS-1 are critical elements of the cGMP-dependent thermotransduction cascade in the AFD neurons responsible for C. elegans thermotaxis. Wang D, et al. J Gen Physiol, 2013 Oct. PMID 24081984, Free PMC Article
    5. The Receptor-Bound Guanylyl Cyclase DAF-11 Is the Mediator of Hydrogen Peroxide-Induced cGMP Increase in Caenorhabditis elegans [corrected]. Beckert U, et al. PLoS One, 2013. PMID 24015261, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-GMP phosphodiesterase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calmodulin binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoric diester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cAMP-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chemosensory behavior IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in chemotaxis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microvillus organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cGMP-mediated signaling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of cGMP-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of cGMP-mediated signaling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of protein kinase C signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phototransduction IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of establishment of cell polarity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to alkaline pH IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to hydrogen peroxide IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to oxygen levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Phosphodiesterase;putative 3',5'-cyclic phosphodiesterase pde-1
    NP_001129790.1
    • Confirmed by transcript evidence
    NP_493343.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      13310887..13318716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060942.5 → NP_493343.1  putative 3',5'-cyclic phosphodiesterase pde-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493343.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O18696
      Conserved Domains (2) summary
      pfam00233
      Location:332 → 558
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:195 → 248
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

    2. NM_001136318.5 → NP_001129790.1  Phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001129790.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5BM35
      Conserved Domains (2) summary
      pfam00233
      Location:201 → 427
      PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
      pfam08499
      Location:64 → 117
      PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O18696.2

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