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    TIM21 Tim21p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852921, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TIM21
    Official Full Name
    Tim21p
    Primary source
    SGD:S000003265
    Locus tag
    YGR033C
    See related
    AllianceGenome:SGD:S000003265; FungiDB:YGR033C; VEuPathDB:YGR033C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in protein import into mitochondrial matrix. Located in mitochondrion. Part of TIM23 mitochondrial import inner membrane translocase complex. Orthologous to human TIMM21 (translocase of inner mitochondrial membrane 21). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TIM21 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (554248..554967, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Imo32p Neighboring gene Nag1p Neighboring gene 1,3-beta-glucan synthase GSC2 Neighboring gene ribosomal 60S subunit protein L26B Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Conformational ensemble of an intrinsically flexible loop in mitochondrial import protein Tim21 studied by modeling and molecular dynamics simulations. Srivastava A, et al. Biochim Biophys Acta Gen Subj, 2020 Feb. PMID 31445064
    2. Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study. Bala S, et al. Biochim Biophys Acta Gen Subj, 2020 Feb. PMID 31449839
    3. The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes. Albrecht R, et al. EMBO Rep, 2006 Dec. PMID 17099692, Free PMC Article
    4. Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders. Aiyar RS, et al. Nat Commun, 2014 Dec 18. PMID 25519239, Free PMC Article
    5. Stendomycin selectively inhibits TIM23-dependent mitochondrial protein import. Filipuzzi I, et al. Nat Chem Biol, 2017 Dec. PMID 28991239, Free PMC Article

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. analysis of a loop segment in Tim21, which is in close proximity of the binding site of Tim23, has different conformations in X-ray, NMR and new crystal contact-free space structures
      Title: Conformational ensemble of an intrinsically flexible loop in mitochondrial import protein Tim21 studied by modeling and molecular dynamics simulations.
    2. loop 2 of yeast Tim21 in the crystal contact-free space adopts a representative, dominant conformation in solution
      Title: Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study.
    3. Three Tim23 motifs bind to a single conserved pocket in Tim21.
      Title: Molecular basis of the dynamic structure of the TIM23 complex in the mitochondrial intermembrane space.
    4. The signal-driven release of Tim21 from Tim50 promotes recruitment of Pam17 and thus triggers formation of the motor-associated form of the TIM23 complex required for matrix transport.
      Title: Signal recognition initiates reorganization of the presequence translocase during protein import.
    5. Tim21 binds to the trans site of the TOM complex thus keeping the two translocases in close contact
      Title: Role of Tim21 in mitochondrial translocation contact sites.
    6. Tim21 interacts with the respiratory chain and promotes membrane-potential-dependent protein sorting into the inner mitochondrial membrane.
      Title: A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein import into mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into mitochondrial matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM23 mitochondrial import inner membrane translocase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of TIM23 mitochondrial import inner membrane translocase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of TIM23 mitochondrial import inner membrane translocase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tim21p
    NP_011547.3
    • Nonessential component of the TIM23 complex; interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate the Translocase of the Inner Mitochondrial membrane (TIM23 complex) activity

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      554248..554967 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181162.3 → NP_011547.3  TPA: Tim21p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011547.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUG9, P53220, Q45U51
      UniProtKB/TrEMBL
      A6ZV21, B3LII7, B5VIZ2, C7GKA1, C8Z8S8, G2WEC3, N1P233
      Conserved Domains (1) summary
      pfam08294
      Location:67 → 219
      TIM21
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53220.1

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