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    Evi5 Ecotropic viral integration site 5 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 32088, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Evi5provided by FlyBase
    Official Full Name
    Ecotropic viral integration site 5provided by FlyBase
    Primary source
    FLYBASE:FBgn0262740
    Locus tag
    Dmel_CG11727
    See related
    AllianceGenome:FB:FBgn0262740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH08923; BcDNA:LD11130; CG11727; Dmel\CG11727; MRE21
    Summary
    Enables GTPase activator activity and small GTPase binding activity. Involved in regulation of cell migration and regulation of protein localization. Located in Golgi apparatus and vesicle. Colocalizes with recycling endosome. Is expressed in several structures, including adult head; central brain primordium; ganglia; gland; and pole plasm. Orthologous to human EVI5 (ecotropic viral integration site 5) and EVI5L (ecotropic viral integration site 5 like). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Evi5 in Genome Data Viewer
    Location:
    10B11-10B14; 1-34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (11430523..11454386, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (11324556..11348419, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Odorant receptor 10a Neighboring gene Gustatory receptor 10a Neighboring gene Glutamine synthetase 2 Neighboring gene Sphingosine kinase 1 Neighboring gene Heterochromatin protein 5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vitro and in vivo characterization of the Rab11-GAP activity of Drosophila Evi5. Laflamme C, et al. Methods Mol Biol, 2015. PMID 25800843
    2. Confirming candidate genes for longevity by RT-qPCR using two different genetic backgrounds and selection methods. Wit J, et al. J Insect Physiol, 2013 Mar. PMID 23357090
    3. Prediction of intestinal stem cell regulatory genes from Drosophila gut damage model created using multiple inducers: Differential gene expression-based protein-protein interaction network analysis. Lee SH, et al. Dev Comp Immunol, 2023 Jan. PMID 36087786
    4. Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions. Soltani S, et al. Nat Commun, 2024 May 14. PMID 38744835, Free PMC Article
    5. Evolution of Tre-2/Bub2/Cdc16 (TBC) Rab GTPase-activating proteins. Gabernet-Castello C, et al. Mol Biol Cell, 2013 May. PMID 23485563, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions.
      Title: Drosophila Evi5 is a critical regulator of intracellular iron transport via transferrin and ferritin interactions.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of protein localization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with recycling endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ecotropic viral integration site 5
    Names
    CG11727-PA
    CG11727-PB
    CG11727-PC
    CG11727-PD
    CG11727-PE
    Evi5-PA
    Evi5-PB
    Evi5-PC
    Evi5-PD
    Evi5-PE
    ecotropic viral integration site 5 ortholog
    mRNA-like ncRNA in embryogenesis 21

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      11430523..11454386 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167285.4 → NP_727526.2  ecotropic viral integration site 5, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_727526.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C9QP48, E1JJH7, F0JAJ2, Q8IR89, Q8MT90, Q95S00, Q9VYY9
      Conserved Domains (2) summary
      smart00164
      Location:113 → 320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15030
      Location:627 → 731
      DUF4527; Protein of unknown function (DUF4527)

    2. NM_001169251.4 → NP_001162722.1  ecotropic viral integration site 5, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162722.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYY9
      Conserved Domains (3) summary
      cl14654
      Location:377 → 517
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00164
      Location:113 → 320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15030
      Location:621 → 725
      DUF4527; Protein of unknown function (DUF4527)

    3. NM_001272521.1 → NP_001259450.1  ecotropic viral integration site 5, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259450.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYY9
      Conserved Domains (3) summary
      cl14654
      Location:377 → 517
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00164
      Location:113 → 320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15030
      Location:621 → 725
      DUF4527; Protein of unknown function (DUF4527)

    4. NM_001169250.2 → NP_001162721.1  ecotropic viral integration site 5, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162721.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYY9
      Conserved Domains (3) summary
      cl14654
      Location:377 → 517
      V_Alix_like; Protein-interacting V-domain of mammalian Alix and related domains
      smart00164
      Location:113 → 320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15030
      Location:621 → 725
      DUF4527; Protein of unknown function (DUF4527)

    5. NM_132488.5 → NP_572716.3  ecotropic viral integration site 5, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572716.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VYY9
      Conserved Domains (2) summary
      smart00164
      Location:113 → 320
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
      pfam15030
      Location:627 → 731
      DUF4527; Protein of unknown function (DUF4527)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95NS4 Q95NS4
    Q9VYY9.3 Q9VYY9

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