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    promL prominin-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38372, updated on 9-Dec-2024

    Summary

    Official Symbol
    promLprovided by FlyBase
    Official Full Name
    prominin-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026189
    Locus tag
    Dmel_CG7740
    See related
    AllianceGenome:FB:FBgn0026189
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    bs29e02.y1; CG7740; Dmel\CG7740; PromL
    Summary
    Involved in microvillus organization. Is active in apical plasma membrane. Is expressed in adult head; fat body; larval brain; and spermatozoon. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12; retinal macular dystrophy 2; and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1) and PROM2 (prominin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See promL in Genome Data Viewer
    Location:
    63B1-63B3; 3-6 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (3114450..3127724, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (3114450..3127724, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene transfer RNA:Cysteine-GCA 1-4 Neighboring gene Chitinase 7 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene transfer RNA:Methionine-CAT 2-1 Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45819 Neighboring gene ALG2, alpha-1,3/1,6-mannosyltransferase

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Component Evidence Code Pubs
    is_active_in apical plasma membrane PubMed 
    located_in membrane  

    General protein information

    Preferred Names
    prominin-like
    Names
    CG7740-PA
    CG7740-PB
    CG7740-PC
    CG7740-PD
    CG7740-PE
    CG7740-PG
    CG7740-PH
    Prominin-like
    promL-PA
    promL-PB
    promL-PC
    promL-PD
    promL-PE
    promL-PG
    promL-PH
    prominin-like protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      3114450..3127724 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259658.3 → NP_001246587.1  prominin-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDX6
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin
    2. NM_167987.4 → NP_728810.1  prominin-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728810.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
      UniProtKB/TrEMBL
      M9PH44
      Related
      FBpp0072980
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin
    3. NM_139513.3 → NP_647770.1  prominin-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647770.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
      UniProtKB/TrEMBL
      M9PH44
      Related
      FBpp0072981
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin
    4. NM_001274424.1 → NP_001261353.1  prominin-like, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261353.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PDX6
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin
    5. NM_167986.1 → NP_728809.1  prominin-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728809.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
      UniProtKB/TrEMBL
      M9PH44
      Related
      FBpp0072982, FBtr0073120
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin
    6. NM_001274422.1 → NP_001261351.1  prominin-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261351.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V1D5, A8WHI2, P82295, Q95RK1, Q9VZV0
      UniProtKB/TrEMBL
      M9PH44
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin; Prominin
    7. NM_001382193.1 → NP_001368963.1  prominin-like, isoform H [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      H5V897, M9PBK6
      Conserved Domains (1) summary
      pfam05478
      Location:76 → 881
      Prominin
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