Blimp-1 Blimp-1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Blimp-1provided by FlyBase
Official Full Name: Blimp-1provided by FlyBase
Primary source: FLYBASE:FBgn0035625
Locus tag: Dmel_CG5249
See related: AllianceGenome:FB:FBgn0035625
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: blimp-1; BLIMP-1; Blimp1; CG5249; dBlimp-1; dBlimp1; Dmel\CG5249
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific. Involved in several processes, including cellular response to ecdysone; compound eye photoreceptor fate commitment; and pupation. Located in nucleus. Is expressed in several structures, including anlage in statu nascendi; antennal anlage; epidermis; gut section; and head epidermis primordium. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and lung adenocarcinoma. Orthologous to human PRDM1 (PR/SET domain 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 64E1-64E1; 3-15 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (5630983..5652094)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (5624083..5645194)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Domain analysis of Drosophila Blimp-1 reveals the importance of its repression function and instability in determining pupation timing.
Title: Domain analysis of Drosophila Blimp-1 reveals the importance of its repression function and instability in determining pupation timing.
The Blimp-1 transcription factor acts in non-neuronal cells to regulate terminal differentiation of the Drosophila eye.
Title: The Blimp-1 transcription factor acts in non-neuronal cells to regulate terminal differentiation of the Drosophila eye.
results suggest that Blimp-1 is degraded by the 26S proteasome and is recruited by FBXO11 in the fat body, which is important for determining pupation timing
Title: Proteasome activity determines pupation timing through the degradation speed of timer molecule Blimp-1.
Blimp-1 regulates the expression of genes involved in chitin deposition and F-actin organization during tracheal maturation.
Title: Blimp-1 Mediates Tracheal Lumen Maturation in Drosophila melanogaster.
The timing of shade expression is determined by its transcriptional activator betaFtz-f1. The betaftz-f1 gene is activated after a decline in the expression of its transcriptional repressor Blimp-1.
Title: A biological timer in the fat body comprising Blimp-1, βFtz-f1 and Shade regulates pupation timing in Drosophila melanogaster.
Blimp-1 gene is transcribed during prepupal development when the ecdysteroid titer is high, but the expressed mRNA degrades rapidly.
Title: Regulatory mechanisms of ecdysone-inducible Blimp-1 encoding a transcriptional repressor that is important for the prepupal development in Drosophila.
These results suggest that the transient transcriptional repressor dBlimp-1 is important for determining developmental timing in the ecdysone-induced pathway.
Title: Drosophila Blimp-1 is a transient transcriptional repressor that controls timing of the ecdysone-induced developmental pathway.
Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.
Title: A homologue of the vertebrate SET domain and zinc finger protein Blimp-1 regulates terminal differentiation of the tracheal system in the Drosophila embryo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to ecdysone	IEP Inferred from Expression Pattern more info	PubMed
involved_in compound eye photoreceptor fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in pupation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of tube architecture, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	HDA more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Blimp-1

Names: Blimp-1-PA; Blimp-1-PB; Blimp-1-PC; Blimp-1-PD; Blimp-1-PE; Blimp-1-PF; CG5249-PA; CG5249-PB; CG5249-PC; CG5249-PD; CG5249-PE; CG5249-PF; dBlimp1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

5630983..5652094

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300016.1 → NP_001286945.1 Blimp-1, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286945.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VRN4

Conserved Domains (3) summary

smart00317
Location:133 → 247

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:879 → 899

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:891 → 916

zf-H2C2_2; Zinc-finger double domain
NM_001274513.1 → NP_001261442.1 Blimp-1, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261442.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBR0

Conserved Domains (3) summary

smart00317
Location:133 → 260

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:892 → 912

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:904 → 929

zf-H2C2_2; Zinc-finger double domain
NM_139725.3 → NP_647982.1 Blimp-1, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_647982.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VRN4

Related

FBpp0076797

Conserved Domains (3) summary

smart00317
Location:133 → 247

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:879 → 899

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:891 → 916

zf-H2C2_2; Zinc-finger double domain
NM_001274514.1 → NP_001261443.1 Blimp-1, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261443.1

Status: REVIEWED

UniProtKB/TrEMBL

M9PBR0

Conserved Domains (3) summary

smart00317
Location:133 → 260

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:892 → 912

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:904 → 929

zf-H2C2_2; Zinc-finger double domain
NM_001274515.1 → NP_001261444.1 Blimp-1, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261444.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VRN4

Conserved Domains (3) summary

smart00317
Location:133 → 247

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:879 → 899

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:891 → 916

zf-H2C2_2; Zinc-finger double domain
NM_001274516.1 → NP_001261445.1 Blimp-1, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261445.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9VRN4

Conserved Domains (3) summary

smart00317
Location:133 → 247

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

sd00017
Location:879 → 899

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:891 → 916

zf-H2C2_2; Zinc-finger double domain