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    MsrA Methionine sulfoxide reductase A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39675, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MsrAprovided by FlyBase
    Official Full Name
    Methionine sulfoxide reductase Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0000565
    Locus tag
    Dmel_CG7266
    See related
    AllianceGenome:FB:FBgn0000565
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7266; Dmel\CG7266; dmsrA; dMsrA; DROZ60MEX; Eip28; Eip28 /29; eip28/29; Eip28/29; Eip71C; Eip71CD; EiP71CD; msrA; MSRA
    Summary
    Enables peptide-methionine (S)-S-oxide reductase activity. Involved in cellular response to oxidative stress and determination of adult lifespan. Predicted to be active in cytoplasm. Is expressed in several structures, including anlage in statu nascendi; embryonic/larval hemocyte; epithelium; fat body; and gut section. Orthologous to human MSRA (methionine sulfoxide reductase A). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See MsrA in Genome Data Viewer
    Location:
    71D3-71D4; 3-43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (15511052..15513202)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (15504152..15506302)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene gdl-ORF39 Neighboring gene Z600 Neighboring gene gonadal Neighboring gene uncharacterized protein Neighboring gene midgut expression 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cDNA clones for the ecdysone-inducible polypeptide (EIP) mRNAs of Drosophila Kc cells. Savakis C, et al. EMBO J, 1984 Jan. PMID 16453496, Free PMC Article
    2. Transcriptional response elements in the promoter of CYP6B1, an insect P450 gene regulated by plant chemicals. Petersen RA, et al. Biochim Biophys Acta, 2003 Feb 17. PMID 12573487
    3. Structure of the Eip28/29 gene, an ecdysone-inducible gene from Drosophila. Cherbas L, et al. J Mol Biol, 1986 Jun 20. PMID 3097323
    4. Alternative splicing generates two distinct Eip28/29 gene transcripts in Drosophila Kc cells. Schulz RA, et al. Proc Natl Acad Sci U S A, 1986 Dec. PMID 3099283, Free PMC Article
    5. Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism. Guan XL, et al. Aging Cell, 2017 Apr. PMID 27790859, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. overexpression of dmsrA in fat body cells caused FOXO to translocate to the nucleus, implying that this possible positive feedback loop between dmsrA and FOXO could potentiate the antioxidant activity of dmsrA and increase the lifespan
      Title: The Drosophila homolog of methionine sulfoxide reductase A extends lifespan and increases nuclear localization of FOXO.
    2. MsrA and MsrB, the two proteins with similar function in antioxidant protein repair, have different effects on aging in fruit flies.
      Title: Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging.
    3. Hormonal regulation of MsrA is implicated in conferring protection against oxidative stress in the Drosophila model.
      Title: Ecdysone induction of MsrA protects against oxidative stress in Drosophila.
    4. Reaction mechanism, evolutionary analysis, and role of zinc for methionine sulfoxide reductase
      Title: Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables L-methionine-(S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide-methionine (S)-S-oxide reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide-methionine (S)-S-oxide reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to oxidative stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur amino acid metabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    methionine sulfoxide reductase A
    Names
    CG7266-PA
    CG7266-PB
    CG7266-PC
    CG7266-PE
    CG7266-PF
    CG7266-PG
    Ecdysone-induced protein 28/29kD
    Eip28/29
    Methionine-S-sulfoxide reductase
    MsrA-PA
    MsrA-PB
    MsrA-PC
    MsrA-PE
    MsrA-PF
    MsrA-PG
    methionine reductase A
    NP_001261878.1
    NP_001261879.1
    NP_524085.2
    NP_730047.1
    NP_730048.1
    NP_996093.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      15511052..15513202
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168623.2 → NP_730048.1  methionine sulfoxide reductase A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730048.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KUN2
      Related
      FBpp0075307
      Conserved Domains (1) summary
      cl00366
      Location:42 → 80
      PMSR; Peptide methionine sulfoxide reductase

    2. NM_079361.3 → NP_524085.2  methionine sulfoxide reductase A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524085.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P08761, Q86NL3, Q8IQM6, Q8IT52, Q9VUP3, Q9VUP4, Q9VUP5
      UniProtKB/TrEMBL
      B5X0L2, Q6NLA4
      Related
      FBpp0075308
      Conserved Domains (1) summary
      pfam01625
      Location:42 → 174
      PMSR; Peptide methionine sulfoxide reductase

    3. NM_001274950.1 → NP_001261879.1  methionine sulfoxide reductase A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261879.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PCL6, Q6NLA4
      Conserved Domains (1) summary
      pfam01625
      Location:42 → 174
      PMSR; Peptide methionine sulfoxide reductase

    4. NM_168622.2 → NP_730047.1  methionine sulfoxide reductase A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730047.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q6NLA4
      Related
      FBpp0075309
      Conserved Domains (1) summary
      pfam01625
      Location:42 → 170
      PMSR; Peptide methionine sulfoxide reductase

    5. NM_206371.3 → NP_996093.2  methionine sulfoxide reductase A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996093.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      F2FB74, Q7KUM8
      Conserved Domains (1) summary
      pfam01625
      Location:35 → 167
      PMSR; Peptide methionine sulfoxide reductase

    6. NM_001274949.1 → NP_001261878.1  methionine sulfoxide reductase A, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261878.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PI66, Q6NLA4
      Conserved Domains (1) summary
      pfam01625
      Location:41 → 173
      PMSR; Peptide methionine sulfoxide reductase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PCL6 M9PCL6
    M9PI66 M9PI66
    P08761.2 P08761
    Q6AWF7 Q6AWF7
    Q7KUM8 Q7KUM8
    Q7KUN2 Q7KUN2

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