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    NUR1 Nur1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851469, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NUR1
    Official Full Name
    Nur1p
    Primary source
    SGD:S000002247
    Locus tag
    YDL089W
    See related
    AllianceGenome:SGD:S000002247; FungiDB:YDL089W; VEuPathDB:YDL089W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in maintenance of rDNA and regulation of exit from mitosis. Located in nuclear periphery. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NUR1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (296820..298274)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene Ubx3p Neighboring gene protein farnesyltransferase Neighboring gene FG-nucleoporin ASM4 Neighboring gene Luc7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast. Godfrey M, et al. PLoS Genet, 2015 Jan. PMID 25569132, Free PMC Article
    2. Nucleolar release of rDNA repeats for repair involves SUMO-mediated untethering by the Cdc48/p97 segregase. Capella M, et al. Nat Commun, 2021 Aug 13. PMID 34389719, Free PMC Article
    3. Role for perinuclear chromosome tethering in maintenance of genome stability. Mekhail K, et al. Nature, 2008 Dec 4. PMID 18997772, Free PMC Article
    4. Nucleolar size regulates nuclear envelope shape in Saccharomyces cerevisiae. Male G, et al. J Cell Sci, 2020 Oct 30. PMID 32973112
    5. CLIP and cohibin separate rDNA from nucleolar proteins destined for degradation by nucleophagy. Mostofa MG, et al. J Cell Biol, 2018 Aug 6. PMID 29959231, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in maintenance of rDNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of rDNA IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exit from mitosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear periphery HDA PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Nur1p
    NP_010194.1
    • Chromosome linkage inner nuclear membrane protein; CLIP, involved in perinuclear chromosome tethering and rDNA repeat stability; involved in regulating mitotic exit; dephosphorylated by Cdc14p in anaphase, which promotes timely rDNA segregation and allows mitotic progression; interacts with Csm1p and Lrs4p; null mutant has elevated levels of unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery; Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      296820..298274
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180148.1 → NP_010194.1  TPA: Nur1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010194.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRQ9, Q12066
      UniProtKB/TrEMBL
      G2WC73
      Conserved Domains (1) summary
      pfam10332
      Location:228 → 313
      DUF2418; Protein of unknown function (DUF2418)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12066.1

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