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    CG11438 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40469, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG11438provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037164
    Locus tag
    Dmel_CG11438
    See related
    AllianceGenome:FB:FBgn0037164
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Css1alpha; Dmel\CG11438; LPP-like; PAP2; WUN-like
    Summary
    Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be active in plasma membrane. Is expressed in embryonic dorsal epidermis; embryonic foregut; embryonic head epidermis; and embryonic ventral epidermis. Orthologous to human PLPP1 (phospholipid phosphatase 1); PLPP2 (phospholipid phosphatase 2); and PLPP3 (phospholipid phosphatase 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG11438 in Genome Data Viewer
    Location:
    79E4-79E4; 3-47 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22465619..22468076)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22458719..22461176)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene lazaro Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The histone methyltransferase G9a regulates tolerance to oxidative stress-induced energy consumption. Riahi H, et al. PLoS Biol, 2019 Mar. PMID 30860988, Free PMC Article
    2. Dependence on the Lazaro phosphatidic acid phosphatase for the maximum light response. Kwon Y, et al. Curr Biol, 2006 Apr 4. PMID 16513351
    3. lazaro encodes a lipid phosphate phosphohydrolase that regulates phosphatidylinositol turnover during Drosophila phototransduction. Garcia-Murillas I, et al. Neuron, 2006 Feb 16. PMID 16476663
    4. Identification of a family of animal sphingomyelin synthases. Huitema K, et al. EMBO J, 2004 Jan 14. PMID 14685263, Free PMC Article
    5. A role for triglyceride lipase brummer in the regulation of sex differences in Drosophila fat storage and breakdown. Wat LW, et al. PLoS Biol, 2020 Jan. PMID 31961851, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG11438-PA
    CG11438-PB
    NP_001287145.1
    NP_649392.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22465619..22468076
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001300216.1 → NP_001287145.1  uncharacterized protein Dmel_CG11438, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNU1
      Conserved Domains (1) summary
      cd03384
      Location:104 → 257
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    2. NM_141135.3 → NP_649392.1  uncharacterized protein Dmel_CG11438, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649392.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNU1
      Related
      FBpp0078156
      Conserved Domains (1) summary
      cd03384
      Location:104 → 257
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VNU1 Q9VNU1

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