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    Drep1 DNA fragmentation factor-related protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36290, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Drep1provided by FlyBase
    Official Full Name
    DNA fragmentation factor-related protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0024732
    Locus tag
    Dmel_CG8357
    See related
    AllianceGenome:FB:FBgn0024732
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG8357; dICAD; Dmel\CG8357; Drep-1; DREP-1; DREP-1/dICAD; drep1; DREP1; ICAD; ICAD/DREP-1; Rep1
    Summary
    Enables protein sequestering activity. Involved in negative regulation of apoptotic process and nurse cell apoptotic process. Is expressed in organism. Human ortholog(s) of this gene implicated in familial partial lipodystrophy type 5 and obesity. Orthologous to human CIDEA (cell death inducing DFFA like effector a); CIDEB (cell death inducing DFFA like effector b); and CIDEC (cell death inducing DFFA like effector c). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Drep1 in Genome Data Viewer
    Location:
    48D8-48D8; 2-65 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (12044612..12050172)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (7932117..7937677)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene upstream of RpIII128 Neighboring gene RNA polymerase III subunit B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene DNA fragmentation factor-related protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A putative role of Drep1 in apoptotic DNA fragmentation system in fly is mediated by direct interaction with Drep2 and Drep4. Park OK, et al. Apoptosis, 2013 Apr. PMID 23417746
    2. Identification and developmental expression of inhibitor of caspase-activated DNase (ICAD) in Drosophila melanogaster. Mukae N, et al. J Biol Chem, 2000 Jul 14. PMID 10781612
    3. In vitro analysis of the complete CIDE domain interactions of the Drep system in fly. Lee SM, et al. Apoptosis, 2014 Mar. PMID 24233238
    4. General interaction mode of CIDE:CIDE complex revealed by a mutation study of the Drep2 CIDE domain. Lee SM, et al. FEBS Lett, 2013 Apr 2. PMID 23485826
    5. A novel activation mechanism of caspase-activated DNase from Drosophila melanogaster. Yokoyama H, et al. J Biol Chem, 2000 Apr 28. PMID 10777599

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study suggests that Drep1 might be involved in apoptotic DNA fragmentation of fly system by direct interaction with Drep2 as well as Drep4
      Title: A putative role of Drep1 in apoptotic DNA fragmentation system in fly is mediated by direct interaction with Drep2 and Drep4.
    2. Data indicate that the basic surface side of Drep2 CIDE is involved in the interaction with the acidic surface side of Drep1 CIDE and Drep3 CIDE.
      Title: General interaction mode of CIDE:CIDE complex revealed by a mutation study of the Drep2 CIDE domain.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables deoxyribonuclease inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein sequestering activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic DNA fragmentation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in nurse cell apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA fragmentation factor-related protein 1
    Names
    CG8357-PA
    CG8357-PB
    DFF45-related protein-1
    Drep1-PA
    Drep1-PB
    Rep1
    inhibitor of CAD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      12044612..12050172
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_136877.5 → NP_610721.2  DNA fragmentation factor-related protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610721.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      O61464, Q6NR36
      Related
      FBpp0087086
      Conserved Domains (1) summary
      smart00266
      Location:12 → 85
      CAD; Domains present in proteins implicated in post-mortem DNA fragmentation

    2. NM_001273980.2 → NP_001260909.1  DNA fragmentation factor-related protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260909.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFQ3, O61464
      Conserved Domains (1) summary
      smart00266
      Location:12 → 85
      CAD; Domains present in proteins implicated in post-mortem DNA fragmentation
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KFQ3 A0A0B4KFQ3
    O61464 O61464
    Q6NR36 Q6NR36

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