Plpp7 phospholipid phosphatase 7 (inactive) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plpp7provided by MGI
Official Full Name: phospholipid phosphatase 7 (inactive)provided by MGI
Primary source: MGI:MGI:2445183
See related: Ensembl:ENSMUSG00000051373 AllianceGenome:MGI:2445183
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NET39; Ppapdc3; D830019K17Rik
Summary: Predicted to enable sphingosine-1-phosphate phosphatase activity. Acts upstream of or within negative regulation of myotube differentiation. Located in nuclear envelope. Is expressed in several structures, including diaphragm; musculature; spleen; testis; and tongue. Orthologous to human PLPP7 (phospholipid phosphatase 7 (inactive)). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in heart adult (RPKM 16.4), mammary gland adult (RPKM 11.8) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 B; 2 22.02 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (31985540..32000827)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (32095528..32110815)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy.
Title: Net39 protects muscle nuclei from mechanical stress during the pathogenesis of Emery-Dreifuss muscular dystrophy.
The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization.
Title: The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization.
Three muscle-specific nuclear membrane proteins, NET39, Tmem38A, and WFS1, direct specific myogenic genes to the nuclear periphery to facilitate their repression during myogenesis.
Title: Tissue-Specific Gene Repositioning by Muscle Nuclear Membrane Proteins Enhances Repression of Critical Developmental Genes during Myogenesis.
The nuclear lamina-associated nuclear envelope transmembrane protein NET39 (Ppapdc3) functions as a negative regulator of myoblast differentiation.
Title: Regulation of myoblast differentiation by the nuclear envelope protein NET39.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

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Markers

RH141132 (e-PCR)
- UniSTS:223128

BB284363 (e-PCR)
- UniSTS:207316

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables lipid phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables sphingosine-1-phosphate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of myotube differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of myotube differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear envelope	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inactive phospholipid phosphatase 7

Names: nuclear envelope transmembrane protein 39; phosphatidic acid phosphatase type 2 domain containing 3; phosphatidic acid phosphatase type 2 domain-containing protein 3; probable lipid phosphate phosphatase PPAPDC3

NP_001342167.1

EC 3.1.3.-

NP_001410151.1

EC 3.1.3.-

NP_663496.1

EC 3.1.3.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355238.1 → NP_001342167.1 inactive phospholipid phosphatase 7 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an alternate exon compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AK048016, AK052883, AK134638

Conserved Domains (1) summary

cl00474
Location:97 → 151

PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
NM_001423222.1 → NP_001410151.1 inactive phospholipid phosphatase 7 isoform 3

Status: VALIDATED

Source sequence(s)

AL928893

UniProtKB/TrEMBL

A0A0A6YWL5

Related

ENSMUSP00000141597.2, ENSMUST00000140762.2
NM_145521.4 → NP_663496.1 inactive phospholipid phosphatase 7 isoform 1

See identical proteins and their annotated locations for NP_663496.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK052883, AK134638

Consensus CDS

CCDS15906.1

UniProtKB/Swiss-Prot

Q91WB2

Related

ENSMUSP00000054337.6, ENSMUST00000057423.6

Conserved Domains (1) summary

cd03391
Location:97 → 255

PAP2_containing_2_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_2. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to eukaryota, lacks functional characterization and may act as a ...