Rilp Rab interacting lysosomal protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rilpprovided by MGI
Official Full Name: Rab interacting lysosomal proteinprovided by MGI
Primary source: MGI:MGI:2144271
See related: Ensembl:ENSMUSG00000038195 AllianceGenome:MGI:2144271
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm857
Summary: Predicted to enable dynein light intermediate chain binding activity and small GTPase binding activity. Predicted to be involved in several processes, including endosomal transport; intralumenal vesicle formation; and regulation of protein catabolic process. Located in mitochondrion. Part of protein-containing complex. Is expressed in brown fat; ileum; liver; male reproductive gland or organ; and metanephros. Orthologous to human RILP (Rab interacting lysosomal protein). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in heart adult (RPKM 16.4), liver adult (RPKM 13.1) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 45.92 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (75400920..75403994)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (75510094..75513168)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy.
Title: Targeting Rab7-Rilp Mediated Microlipophagy Alleviates Lipid Toxicity in Diabetic Cardiomyopathy.
A Novel Role for RILP in Regulating Osteoclastogenesis and Bone Resorption.
Title: A Novel Role for RILP in Regulating Osteoclastogenesis and Bone Resorption.
Cln1-mutations suppress Rab7-RILP interaction and impair autophagy contributing to neuropathology in a mouse model of infantile neuronal ceroid lipofuscinosis.
Title: Cln1-mutations suppress Rab7-RILP interaction and impair autophagy contributing to neuropathology in a mouse model of infantile neuronal ceroid lipofuscinosis.
A new pathway regulating insulin secretion and a novel function of RILP in modulating insulin secretion through mediating the lysosomal degradation of proinsulin.
Title: RILP Restricts Insulin Secretion Through Mediating Lysosomal Degradation of Proinsulin.
The up-regulation of Rab11, Rab7, or RILP, but not its truncated form RILP-C33, rescued LAMP2A-defective trafficking in cystinosis, whereas dominant-negative Rab11 or Rab7 impaired LAMP2A trafficking.
Title: Cystinosin, the small GTPase Rab11, and the Rab7 effector RILP regulate intracellular trafficking of the chaperone-mediated autophagy receptor LAMP2A.
A new mechanism by which the dynein-dynactin motor complex recognizes Mreg on mature melanosomes is revealed through interaction with RILP and is involved in the centripetal movement of melanosomes.
Title: Melanoregulin regulates retrograde melanosome transport through interaction with the RILP-p150Glued complex in melanocytes.
Rab36 mediates retrograde melanosome transport in melanocytes through interaction with RILP.
Title: The Rab interacting lysosomal protein (RILP) homology domain functions as a novel effector domain for small GTPase Rab36: Rab36 regulates retrograde melanosome transport in melanocytes.
CD63, but not RILP, is recruited to the phagosomes in macrophages expressing the dominant negative form of Rab7.
Title: Differential recruitment of CD63 and Rab7-interacting-lysosomal-protein to phagosomes containing Mycobacterium tuberculosis in macrophages.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:492132

AI835553 (e-PCR)
- UniSTS:164467

D11Bwg0410e (e-PCR), detects polymorphism
- UniSTS:141716

RH136405 (e-PCR)
- UniSTS:210395

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dynein light intermediate chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light intermediate chain binding	IEA Inferred from Electronic Annotation more info
enables dynein light intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	IEA Inferred from Electronic Annotation more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to late endosome transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in early endosome to late endosome transport	IEA Inferred from Electronic Annotation more info
involved_in early endosome to late endosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome to lysosome transport	IEA Inferred from Electronic Annotation more info
involved_in endosome to lysosome transport	ISO Inferred from Sequence Orthology more info
involved_in endosome transport via multivesicular body sorting pathway	IEA Inferred from Electronic Annotation more info
involved_in endosome transport via multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in intralumenal vesicle formation	IEA Inferred from Electronic Annotation more info
involved_in intralumenal vesicle formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome membrane	IEA Inferred from Electronic Annotation more info
located_in lysosomal membrane	IEA Inferred from Electronic Annotation more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: rab-interacting lysosomal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.