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    Mes2 Mesoderm-expressed 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40514, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mes2provided by FlyBase
    Official Full Name
    Mesoderm-expressed 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0037207
    Locus tag
    Dmel_CG11100
    See related
    AllianceGenome:FB:FBgn0037207
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    adfR; CG11100; Dmel\CG11100; mes-2; mes2; MES2
    Summary
    Involved in ecdysis, chitin-based cuticle and instar larval development. Located in nucleus. Is expressed in several structures, including endoderm anlage; glial cell; head epidermis primordium; mesoderm; and visceral mesoderm derivative. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Mes2 in Genome Data Viewer
    Location:
    80C1-80C1; 3-47 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22945657..22952248)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22938757..22945348)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mir-9388 stem loop Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45758

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Promoter elements associated with RNA Pol II stalling in the Drosophila embryo. Hendrix DA, et al. Proc Natl Acad Sci U S A, 2008 Jun 3. PMID 18505835, Free PMC Article
    2. I-KCKT allows dissection-free RNA profiling of adult Drosophila intestinal progenitor cells. Buddika K, et al. Development, 2021 Jan 7. PMID 33246929, Free PMC Article
    3. Synchronous and stochastic patterns of gene activation in the Drosophila embryo. Boettiger AN, et al. Science, 2009 Jul 24. PMID 19628867, Free PMC Article
    4. PIF-like transposons are common in drosophila and have been repeatedly domesticated to generate new host genes. Casola C, et al. Mol Biol Evol, 2007 Aug. PMID 17556756
    5. Developmental Robustness: The Haltere Case in Drosophila. Giraud G, et al. Front Cell Dev Biol, 2021. PMID 34368162, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in ecdysis, chitin-based cuticle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in instar larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Mesoderm-expressed 2
    Names
    CG11100-PB
    CG11100-PC
    Mes2-PB
    Mes2-PC

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      22945657..22952248
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168979.4 → NP_730768.1  Mesoderm-expressed 2, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730768.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VNP3
      Related
      FBpp0078212
      Conserved Domains (1) summary
      smart00595
      Location:62 → 149
      MADF; subfamily of SANT domain

    2. NM_168980.2 → NP_730769.2  Mesoderm-expressed 2, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730769.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IG95, Q8IPS2
      Related
      FBpp0078214
      Conserved Domains (1) summary
      smart00595
      Location:1 → 84
      MADF; subfamily of SANT domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IG95 Q8IG95
    Q95ST8 Q95ST8
    Q9VNP3 Q9VNP3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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