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    HSPE1 heat shock protein family E (Hsp10) member 1 [ Homo sapiens (human) ]

    Gene ID: 3336, updated on 10-Dec-2024

    Summary

    Official Symbol
    HSPE1provided by HGNC
    Official Full Name
    heat shock protein family E (Hsp10) member 1provided by HGNC
    Primary source
    HGNC:HGNC:5269
    See related
    Ensembl:ENSG00000115541 MIM:600141; AllianceGenome:HGNC:5269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EPF; CPN10; GROES; HSP10
    Summary
    This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.[provided by RefSeq, Feb 2011]
    Expression
    Ubiquitous expression in adrenal (RPKM 184.7), kidney (RPKM 90.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See HSPE1 in Genome Data Viewer
    Location:
    2q33.1
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (197500379..197503449)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (197983980..197987052)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (198365103..198368173)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124907951 Neighboring gene coenzyme Q10B Neighboring gene small nucleolar RNA, H/ACA box 105B Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12213 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12214 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16939 Neighboring gene HSPE1-MOB4 readthrough Neighboring gene heat shock protein family D (Hsp60) member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12215 Neighboring gene MOB family member 4, phocein Neighboring gene uncharacterized LOC124907952 Neighboring gene RNY5 pseudogene 2 Neighboring gene raftlin family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of heat shock 10kDa protein 1 (HSPE1; HSP10) in Jurkat cells PubMed
    integrase gag-pol HSP10 interacts with HIV-1 integrase, which is a substrate for the hHSP60-HSP10 complex PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding HDA PubMed 
    enables metal ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables unfolded protein binding NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    10 kDa heat shock protein, mitochondrial
    Names
    10 kDa chaperonin
    chaperonin 10
    early-pregnancy factor
    epididymis secretory sperm binding protein
    heat shock 10kD protein 1 (chaperonin 10)
    heat shock 10kDa protein 1
    heat shock protein family E member 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008914.1 RefSeqGene

      Range
      5383..8453
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002157.3NP_002148.1  10 kDa heat shock protein, mitochondrial

      See identical proteins and their annotated locations for NP_002148.1

      Status: REVIEWED

      Source sequence(s)
      BC023518, BG188453
      Consensus CDS
      CCDS2320.1
      UniProtKB/Swiss-Prot
      O95421, P61604, Q04984, Q53X54, Q9UDH0
      UniProtKB/TrEMBL
      A0A384N6A4, Q9UNM1
      Related
      ENSP00000233893.5, ENST00000233893.10
      Conserved Domains (1) summary
      cd00320
      Location:8100
      cpn10; Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      197500379..197503449
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      197983980..197987052
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)