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| Status |
Public on Aug 25, 2017 |
| Title |
miRNA expression in Anopheles gambiae tissues |
| Platform organisms |
Tribolium castaneum; Bombyx mori; Aedes aegypti; Anopheles gambiae; Culex quinquefasciatus; Drosophila melanogaster; Apis mellifera |
| Sample organism |
Anopheles gambiae |
| Experiment type |
Non-coding RNA profiling by array
|
| Summary |
Anopheles gambiae mosquitoes transmit the human malaria parasite Plasmodium falciparum, which causes the majority of fatal malaria cases worldwide. The hematophagous life style defines the mosquito reproductive biology and is exploited by P. falciparum for its own sexual reproduction and transmission. The two main phases of the mosquito reproductive cycle, pre-vitellogenic (PV) and post-blood meal (PBM) shape its capacity to transmit malaria. Transition between these phases is tightly coordinated to ensure homeostasis between mosquito tissues and successful reproduction. One layer of control is provided by microRNAs, well-known regulators of blood meal digestion and egg development in mosquitoes. Here, we report a global overview of tissue-specific miRNA expression during the PV and PBM phases and identify miRNAs regulated during PV to PBM transition. The observed coordinated changes in the expression levels of a set of miRNAs in the energy-storing tissues suggest a role in the regulation of blood meal-induced metabolic changes.
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| Overall design |
40 samples were analyzed.
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| Contributor(s) |
Levashina EA, Lampe L |
| Citation missing |
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| |
| Submission date |
Aug 24, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Lena Lampe |
| Organization name |
Max-Planck-Institute for Infection Biology
|
| Street address |
Charitéplatz 1
|
| City |
Berlin |
| ZIP/Postal code |
13357 |
| Country |
Germany |
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| Platforms (1) |
| GPL23950 |
Agilent-049943 mosquito array [probe name version] |
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| Samples (40)
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| Relations |
| BioProject |
PRJNA399852 |
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