|
| Status |
Public on Feb 18, 2019 |
| Title |
Anti-cancer drugs curaxins target the 3D genome organization [HiC] |
| Organism |
Homo sapiens |
| Experiment type |
Other
|
| Summary |
We have recently discovered a class of anti-cancer agents, curaxins, which suppress transcription of oncogenes. Here we demonstrate that curaxins preferentially downregulate expression of genes controlled by enhancers and super-enhancers via interrupting enhancer/promoter spatial communication. Our observations made both on a model of enhancer-regulated transcription of chromatinized template and on cultured cancer cells allow classifying curaxins as a novel type of epigenetic drugs that target the 3D genome organization.
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| |
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| Overall design |
Processed and raw HiC data for control and CBL0137-treated HT1080 cells.
|
| |
|
| Contributor(s) |
Luzhin A, Razin S |
| Citation(s) |
30926878 |
| |
| Submission date |
Jul 24, 2018 |
| Last update date |
Apr 09, 2019 |
| Contact name |
Artem Luzhin |
| E-mail(s) |
[email protected]
|
| Organization name |
Institute of Gene Biology RAS
|
| Street address |
Vavilova 34/5
|
| City |
Moscow |
| ZIP/Postal code |
119334 |
| Country |
Russia |
| |
|
| Platforms (1) |
| GPL21290 |
Illumina HiSeq 3000 (Homo sapiens) |
|
| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE122463 |
Anti-cancer drugs curaxins target the 3D genome organization |
|
| Relations |
| BioProject |
PRJNA482566 |
| SRA |
SRP154986 |
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