|
| Status |
Public on Jun 30, 2019 |
| Title |
MYCN knock-down leads to DNA-repair deficiency in human neuroblastoma (Mnase-Seq) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We knock down MYCN in human neuroblastoma cell line by RNAi. MYCN knock-down caused global epigenome change, including nucleosome gain on key DNA-repair genes and promoter H3K9ac down regulation.
|
| |
|
| Overall design |
Mnase-seq of nucleosome positioning in ctrl/N-myc_kd neuroblastoma cell line BE2C
|
| |
|
| Contributor(s) |
Zheng W, Hu X, Jiang C |
| Citation(s) |
31396265 |
| |
| Submission date |
Oct 04, 2018 |
| Last update date |
Aug 21, 2019 |
| Contact name |
Weisheng Zheng |
| E-mail(s) |
[email protected]
|
| Organization name |
Tongji University
|
| Department |
Department of Bioinformatics
|
| Lab |
Jiang Lab
|
| Street address |
Siping Road, No.1239
|
| City |
Shanghai |
| ZIP/Postal code |
200092 |
| Country |
China |
| |
|
| Platforms (2) |
|
| Samples (4)
|
|
| This SubSeries is part of SuperSeries: |
| GSE120859 |
MYCN knock-down leads to DNA-repair deficiency in human neuroblastoma |
|
| Relations |
| BioProject |
PRJNA494723 |
| SRA |
SRP163490 |
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