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Series GSE12160 Query DataSets for GSE12160
Status Public on Oct 23, 2018
Title Expression profiling of Hyperoxia-Tolerant Drosophila melanogaster
Organism Drosophila melanogaster
Experiment type Expression profiling by array
Summary One of the critical substances that mammals highly regulate via the respiratory, cardiovascular and neurologic systems is O2. Both low and high O2 levels can induce major morbidities as well as mortality. Indeed, O2 has been often considered as both an elixir and a poison in humans. In current study, we have used an experimental selection approach to generate Drosophila strains that are tolerant to severe hyperoxic environment. Gene expression profiling is then applied to investigate the mechanisms underlying hyperoxia tolerance in the newly generated strains.
 
Overall design 27 isogenic D. melanogaster Lines were pooled and following long-term selection over generations with increased oxygen level in the culture environment. The differences in gene expression were compared between adapted flies and generation matched naive controls by microarray.
 
Contributor(s) Zhou D, Zhao H, Haddad GG
Citation(s) 20668515
Submission date Jul 18, 2008
Last update date Oct 23, 2018
Contact name Dan Zhou
E-mail(s) [email protected]
Phone 858-822-6889
Fax 858-534-6971
Organization name University of California, San Diego, School of Medicine
Department Pediatrics
Lab Haddad Lab
Street address CMG 103, 9500 Gilman Drive, MC0735
City La Jolla
State/province CA
ZIP/Postal code 92093-0735
Country USA
 
Platforms (1)
GPL1322 [Drosophila_2] Affymetrix Drosophila Genome 2.0 Array
Samples (24)
GSM306107 Expression profiling of hyperoxia-tolerant Drosophila melanogaster (C1L1)
GSM306108 Expression profiling of Hyperoxia-Tolerant Drosophila melanogaster (C1L2)
GSM306109 Expression profiling of Hyperoxia-Tolerant Drosophila melanogaster (C2L1)
Relations
BioProject PRJNA113447

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12160_RAW.tar 49.8 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
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