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| Status |
Public on Jan 10, 2019 |
| Title |
Arid1a loss drives nonâalcoholic steatohepatitis in mice via epigenetic dysregulation of hepatic lipogenesis and fatty acid oxidation |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
ARID1A, a DNA-binding component of the SWI/SNF ATP-dependent chromatin-remodeling complex, contributes to nucleosome repositioning and access by transcriptional regulators. Liver-specific deletion of Arid1a (Arid1a LKO) caused the development of age-dependent fatty liver disease in mice. Transcriptome analysis revealed upregulation of lipogenesis and down-regulation of fatty acid oxidation genes.
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| |
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| Overall design |
Livers of P90-day-old mice were collected, and transcriptomic analysis performed via RNA-seq.
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| |
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| Contributor(s) |
Moore A, Zhu H, Luo X |
| Citation(s) |
30584660 |
| |
| Submission date |
Jan 04, 2019 |
| Last update date |
Apr 16, 2019 |
| Contact name |
Xuxu Sun |
| Organization name |
shanghai jiao tong university
|
| Department |
school of medicine
|
| Street address |
227 south chongqing road
|
| City |
shanghai |
| ZIP/Postal code |
200025 |
| Country |
China |
| |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA513073 |
| SRA |
SRP175357 |
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