|
| Status |
Public on Feb 20, 2009 |
| Title |
Differentially regulated genes in control and c-myc N-myc deficient progenitors |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Analysis of HSCs from control and c-myc N-myc deficient long-term hematopoietic stem cells. HSCs lacking both c-myc and N-myc display increased apoptosis rates. Data provide insight into the molecular changes occuring upon complete loss of Myc activity, clarifying the resulting apoptotic mechanism and the role of Myc family proteins in HSCs and commited progenitors.
|
| |
|
| Overall design |
Commited progenitors (Lin-Sca1+CD150+CD48+) cells were sorted from the BM of MxCre c-myc flox2 N-myc flox2 (experimental) and c-myc flox2 N-myc flox2 (control) mice 3 days after the last pI-pC injection. Each condition was analysed in triplicates, with each replicate consisting of a pool of 3 dKO mice or 2 control mice.
|
| |
|
| Contributor(s) |
Laurenti E, Finney Bv, Wilson A, Ferrero I, Blanco-Bose WE, Ehninger A, Knoepfler PS, Cheng P, MacDonald R, Eisenman RN, Bernstein ID, Trumpp A |
| Citation(s) |
19041778 |
| |
| Submission date |
Aug 24, 2008 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Elisa Laurenti |
| E-mail(s) |
[email protected]
|
| Phone |
0041216925816
|
| Organization name |
EPFL
|
| Department |
ISREC
|
| Lab |
Trumpp
|
| Street address |
Chemin Des Boveresses 155
|
| City |
Epalinges |
| ZIP/Postal code |
1066 |
| Country |
Switzerland |
| |
|
| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
|
| Samples (6)
|
|
| This SubSeries is part of SuperSeries: |
| GSE12538 |
Differentially regulated genes in control and c-myc N-myc deficient LT-HSCs and progenitors |
|
| Relations |
| BioProject |
PRJNA114237 |
Less...
More...