|
| Status |
Public on Jul 30, 2019 |
| Title |
Couple transcriptome and genomic data obtained from the PDXs to identify pathways linking oncogenic alterations |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: Study the changes in cell transcriptome in breast cancer with respect to normal breast tissue in association with somatic mutations
Methods: RNA was extracted from frozen normal breast tissues and PDXs cells
Results: We found over-expression of oncogenic pathways associated with oncogenic mutations in PDXs
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| |
|
| Overall design |
Analysis of differential gene expression in metastatic breast cancer PDXs
|
| |
|
| Contributor(s) |
Punzi S, Meliksetyan M, Riva L, Marocchi F, Pruneri G, Criscitiello C, Orsi F, Spaggiari L, Curigliano G, Pelicci PG, Lanfrancone L |
| Citation(s) |
31216647 |
| |
| Submission date |
Apr 10, 2019 |
| Last update date |
Jul 30, 2019 |
| Contact name |
Marine Melixetian |
| E-mail(s) |
[email protected]
|
| Organization name |
European Institute of Oncology
|
| Street address |
via Adamello 16
|
| City |
Milano |
| ZIP/Postal code |
20141 |
| Country |
Italy |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (21)
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|
| Relations |
| BioProject |
PRJNA531824 |
| SRA |
SRP191759 |
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