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Series GSE130078 Query DataSets for GSE130078
Status Public on Oct 28, 2019
Title A Novel LincRNA HERES Epigenetically Regulates Wnt Signaling Pathway via Interaction with EZH2 in Esophageal Squamous Cell Carcinoma
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
Summary Esophageal squamous cell carcinoma (ESCC), a major type of primary esophageal cancer in developing countries, displays a very poor clinical outcome in five-year survival rate. Although long non-coding RNAs (lncRNAs) exert critical roles in cancer development, the promising therapeutic targets of ESCC-expressed lncRNAs have not been comprehensively examined and their cancer-driving roles remain largely unknown at the mechanistic level. In this study, we aimed to identify ESCC-driving lncRNAs in the transcriptome level and exploit a therapeutic target with understanidng their modes of action.
 
Overall design High-throughput RNA sequencing (RNA-seq) was performed with rRNA-depleted, total RNAs prepared from paired cancerous and non-cancerous tissues of 23 Korean ESCC patients, and the RNA-seq data were profiled to identify ESCC-driving lncRNAs.
 
Contributor(s) Nam J, Lee S
Citation(s) 31732666
Submission date Apr 19, 2019
Last update date Dec 17, 2019
Contact name Jin-Wu Nam
E-mail(s) [email protected]
Phone +82 2-2220-2428
Organization name Hanyang University
Department Department of Life Science
Street address Seongdong-Gu Hangdang-dong
City Seoul
ZIP/Postal code 133-791
Country South Korea
 
Platforms (1)
GPL11154 Illumina HiSeq 2000 (Homo sapiens)
Samples (46)
GSM3731534 Patient_01_normal
GSM3731535 Patient_01_cancer
GSM3731536 Patient_02_normal
Relations
BioProject PRJNA533799
SRA SRP193095

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE130078_RAW.tar 13.2 Mb (http)(custom) TAR (of TXT)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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