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| Status |
Public on Apr 23, 2019 |
| Title |
Combinatorial discriminant analysis applied to RNAseq data reveals a set of 10 transcripts as signatures of infection of cattle with Mycobacterium avium subsp. Paratuberculosis (MAP). |
| Organism |
Bos taurus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNAseq experimental data of cattle positive to MAP infection are compared to negative uninfected controls, with the purpose to find a small set of differentially expressed genes able to discriminate between infected animals in a preclinical phase. A signature of 10 transcripts that differentiate between potentially infected, but clinically healthy, animals belonging to paratuberculosis positive herds and negative unexposed animals has been identified and crossvalidated.
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| Overall design |
Total RNA was extracted from whole blood of 4-5 years old dairy cattles between the 170-190 days in milk belonging to infected and healthy herds. Animals from the infected herd categorized as positive or potentially exposed to the disease.
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| |
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| Contributor(s) |
Minozzi G, Remondini D |
| Citation(s) |
32033399 |
| |
| Submission date |
Apr 22, 2019 |
| Last update date |
Feb 15, 2020 |
| Contact name |
Daniel Remondini |
| E-mail(s) |
[email protected]
|
| Organization name |
Bologna University
|
| Department |
Physics and Astronomy - DIFA
|
| Street address |
Viale Berti Pichat 6/2
|
| City |
Bologna |
| ZIP/Postal code |
40127 |
| Country |
Italy |
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| Platforms (1) |
| GPL15749 |
Illumina HiSeq 2000 (Bos taurus) |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA534039 |
| SRA |
SRP193314 |
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