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| Status |
Public on Oct 27, 2021 |
| Title |
Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Intestinal stem cells are required for proliferation, differentiation, and regeneration of the intestinal epithelium. Krüppel-like factor 5 regulates intestinal stem cells in both physiologic and pathological conditions and may be a treatment target in certain diseases of the intestine.
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| |
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| Overall design |
ChIP-seq analysis of control mouse intestinal stem cells and Klf5-deleted intestinal stem cells.
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| |
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| Contributor(s) |
Kim C, Saxena M, Maharjan K, Song JJ, Shroyer KR, Bialkowska AB, Shivdasani RA, Yang VW |
| Citation(s) |
31778829 |
| |
| Submission date |
May 15, 2019 |
| Last update date |
Oct 27, 2021 |
| Contact name |
Ramesh Shivdasani |
| E-mail(s) |
[email protected]
|
| Organization name |
Dana Farber Cancer Institute
|
| Department |
Medical Oncology
|
| Lab |
Shivdasani
|
| Street address |
450 Brookline Ave. Dana 720D
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
|
| Platforms (1) |
|
| Samples (5)
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| This SubSeries is part of SuperSeries: |
| GSE131278 |
Krüppel-like factor 5 regulates stemness, lineage specification, and regeneration of intestinal epithelial stem cells |
|
| Relations |
| BioProject |
PRJNA543102 |
| SRA |
SRP198500 |
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