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Series GSE131978 Query DataSets for GSE131978
Status Public on Nov 14, 2019
Title FXYD5 (dysadherin) upregulation predicts shorter survival and reveals platinum resistance in high-grade serous ovarian cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary High-grade serous ovarian carcinoma (HGSOC) is generally associated with a very dismal prognosis. Nevertheless, patients with similar clinicopathological characteristics can have markedly different clinical outcomes. Our aim was the identification of novel molecular determinants influencing survival.
Gene expression profiles of 12 HGSOC long-term and 27 short-term survivors (training set) were generated by microarray, and a prognostic signature was identified and further evaluated on an independent extensive HGSOC dataset through a meta-analysis approach.
 
Overall design Snap-frozen tumor biopsies were obtained at primary surgery from 39 HGSOC patients: 27 short-term survivors, who lived less than 3 years after initial diagnosis, and 12 long-term survivors, who lived more than 7 years. Total RNA was extracted and hybridized to Affymetrix oligonucleotide microarray chips. On the basis of their Platinum Free Interval (PFI), defined as the time between the last dose of first-line carboplatin-based chemotherapy and the date of tumor progression, HGSOC patients were defined as “resistant” (PFI<6 months), “partially sensitive” (PFI 6-12 months), and “sensitive” (PFI>12 months).
 
Contributor(s) Ravaggi A, Tassi RA
Citation(s) 31434988
Submission date May 30, 2019
Last update date Nov 16, 2019
Contact name Antonella Ravaggi
E-mail(s) [email protected]
Organization name University of Brescia
Department Department of Clinical and Experimental Sciences
Lab Division of Obstetrics and Gynecology
Street address Viale Europa 11
City Brescia
State/province Brescia
ZIP/Postal code 25123
Country Italy
 
Platforms (2)
GPL96 [HG-U133A] Affymetrix Human Genome U133A Array
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (39)
GSM3833263 KOV105: Short-term Survivor (HG-U133A)
GSM3833264 KOV104: Short-term Survivor (HG-U133A)
GSM3833265 KOV55: Short-term Survivor (HG-U133A)
Relations
BioProject PRJNA545492

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE131978_HG-U133A_Matrix.xlsx 7.5 Mb (ftp)(http) XLSX
GSE131978_HG-U133_Plus_2_Matrix.xlsx 10.7 Mb (ftp)(http) XLSX
GSE131978_RAW.tar 156.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table
Processed data are available on Series record
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