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| Status |
Public on Jun 30, 2020 |
| Title |
beta-glucan-induced trained immunity protects against Leishmania braziliensis infection: a crucial role for IL-32 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
We reported the first definitive characterization of the role of IL-32 in the trained phenotype, the results of which improve our understanding of the molecular mechanisms governing trained immunity and Leishmania infection control.
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| Overall design |
Examination of the influence of IL32 rs4786370 SNP in the gene expression in bone marrow granulocyte macrophage progenitors (GMP) of healthy volunteers prior and on day 0 and day 90 (M3) post BCG vaccination. GMPs were identified as Lin-CD34+CD38+CD45RA+CD10- events and purified using FACS.
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| Contributor(s) |
dos Santos JC, Cirovic B, de Bree CL, Schultze JL, Netea MG, Schlitzer A, Joosten LA |
| Citation(s) |
31484076 |
| |
| Submission date |
Jun 04, 2019 |
| Last update date |
Jun 30, 2020 |
| Contact name |
Branko Cirovic |
| Organization name |
LIMES
|
| Lab |
Myeloid Cell Biology
|
| Street address |
Carl-Troll Str 31
|
| City |
Bonn |
| ZIP/Postal code |
53111 |
| Country |
Germany |
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| Platforms (1) |
| GPL18460 |
Illumina HiSeq 1500 (Homo sapiens) |
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| Samples (40)
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| Relations |
| BioProject |
PRJNA546242 |
| SRA |
SRP200387 |
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