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| Status |
Public on Oct 01, 2019 |
| Title |
The function of the Hedgehog signaling pathway in colonic adenomagenesis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The morphogen Indian Hedgehog plays a very important role during intestinal embryogenesis, but also maintains homeostasis in the adult gut. Intestinal Hedgehog is expressed by the intestinal epithelium and signals in paracrine manner
to fibroblasts in the stromal compartment. We studied the stromal changes upon simultaneous homozygous deletion of Ihh and the tumor-suppressor gene Apc in the colon.
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| Overall design |
Epcam-CD45-CD31-gp38+ fibroblasts were isolated from induced VillinCre-ERT2-ZsGreen-IhhKO-ApcKO mice and RNA was isolated.
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| Contributor(s) |
Westendorp BF, van den Brink GR |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Jul 18, 2019 |
| Last update date |
Oct 03, 2019 |
| Contact name |
Barbara Florien Westendorp |
| E-mail(s) |
[email protected]
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| Organization name |
Academic Medical Center
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| Department |
Tytgat Institute for Liver and Intestinal Research
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| Lab |
Gijs van den Brink
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| Street address |
Meibergdreef 69-71
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| City |
Amsterdam |
| State/province |
Noord-Holland |
| ZIP/Postal code |
1105 BK |
| Country |
Netherlands |
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| Platforms (1) |
| GPL20775 |
[MTA-1_0] Affymetrix Mouse Transcriptome Array 1.0 [transcript (gene) CSV version] |
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| Samples (24)
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| GSM3949187 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcWT, A1 gp38 |
| GSM3949188 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcWT, A2 gp38 |
| GSM3949189 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcWT, A3 gp38 |
| GSM3949190 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcWT, A4 gp38 |
| GSM3949191 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcWT, A5 gp38 |
| GSM3949192 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcWT, A6 gp38 |
| GSM3949193 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcWT, A8 gp38 |
| GSM3949194 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcKO, A9 gp38 |
| GSM3949195 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcKO, B1 gp38 |
| GSM3949196 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcKO, B2 gp38 |
| GSM3949197 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcKO, B3 gp38 |
| GSM3949198 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcKO, B4 gp38 |
| GSM3949199 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcKO, B5 gp38 |
| GSM3949200 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcKO, B7 gp38 |
| GSM3949201 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhWT-ApcKO, B8 gp38 |
| GSM3949202 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhKO-ApcKO, B9 gp38 |
| GSM3949203 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhKO-ApcKO, C1 gp38 |
| GSM3949204 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhKO-ApcKO, C2 gp38 |
| GSM3949205 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhKO-ApcKO, C3 gp38 |
| GSM3949206 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhKO-ApcKO, C4 gp38 |
| GSM3949207 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhKO-ApcKO, C5 gp38 |
| GSM3949208 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhKO-ApcKO, C6 gp38 |
| GSM3949209 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhKO-ApcKO, C7 gp38 |
| GSM3949210 |
Colon fibroblasts, Villincre-ERT2-ZsGreen-IhhKO-ApcKO, C9 gp38 |
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| Relations |
| BioProject |
PRJNA555202 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE134469_RAW.tar |
593.4 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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