|
| Status |
Public on Aug 26, 2019 |
| Title |
Endothelial TGFb signaling drives vascular inflammation and atherosclerosis [ChIP-Seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Endothelial TGFβ signaling is one of the primary drivers of atherosclerosis-associated vascular inflammation. Inhibition of endothelial TGFβ signaling in hyperlipidemic mice reduces vessel wall inflammation and vascular permeability and leads to arrest of disease progression and regression of established lesions. We performed scRNAseq method to examine endothelial cell gene expression profile using Apoe and EC specific TGFbR1/2 KO in Apoe background mice.
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| |
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| Overall design |
Examination of endothelial cell TGFb signaling downstream transcription factor Smad2/3 in the regulation of inflammatory gene promoters.
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| |
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| Contributor(s) |
Simons M, Chen P |
| Citation(s) |
31572976 |
| NIH grant(s) |
| Grant ID |
Grant title |
Affiliation |
Name |
| R01 HL135582 |
Endothelial-to-mesenchyma transition and atherosclerosis |
YALE UNIVERSITY |
Michael Simons |
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| |
| Submission date |
Jul 19, 2019 |
| Last update date |
Nov 25, 2019 |
| Contact name |
Michael Simons |
| E-mail(s) |
[email protected]
|
| Organization name |
Yale University
|
| Department |
Department: Internal Medicine Cardiology
|
| Lab |
Yale Cardiovascular Research Center
|
| Street address |
3oo George St, Suite 773
|
| City |
New Haven |
| State/province |
CT |
| ZIP/Postal code |
06511 |
| Country |
USA |
| |
|
| Platforms (1) |
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| Samples (16)
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| This SubSeries is part of SuperSeries: |
| GSE134558 |
Endothelial TGFb signaling drives vascular inflammation and atherosclerosis |
|
| Relations |
| BioProject |
PRJNA555593 |
| SRA |
SRP215473 |
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