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| Status |
Public on Jun 24, 2020 |
| Title |
Epigenetic changes in human DIPG cells with histone H3K27M mutations [ATAC-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We assessed changes in chromatin accessibility in H3.3K27M DIPG cell lines on knockdown of metabolic enzymes including HK2, GDH and IDH1
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| |
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| Overall design |
Hexokinase-2 (HK2), Glutamate dehydrogenase (GLUD1) or insocitrate dehydrogenase (IDH1) were knocked down in H3.3K27M HSJD-DIPG007 cells. Genomic changes in chromatin accessibility were assessed between each shRNA and non-targeted NT controls.
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| |
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| Contributor(s) |
Venneti S |
| Citation(s) |
32795401 |
| |
| Submission date |
Aug 05, 2019 |
| Last update date |
Nov 03, 2023 |
| Contact name |
Sriram Venneti |
| E-mail(s) |
[email protected]
|
| Organization name |
University of Michigan
|
| Street address |
3520E MSRB 1, 1150 W. Medical Center Dr.
|
| City |
Ann Arbor |
| State/province |
MI |
| ZIP/Postal code |
48109 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18573 |
Illumina NextSeq 500 (Homo sapiens) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE135419 |
Epigenetic changes in mouse neuronal stem cells and human DIPG cells with histone H3K27M mutations |
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| Relations |
| BioProject |
PRJNA558794 |
| SRA |
SRP217515 |
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