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| Status |
Public on Oct 29, 2019 |
| Title |
Genome-wide maping of chromatin state and gene exoression in hematopoietic stem and progenitor cells. |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
|
| Summary |
We report the application of H3K27me3 ChI-seq assays in hematopoietic stem and progenitors cells (HSPCs) from p53+/+ and p53R248W/+ mutant mice. We also performed RNA-seq assays to examine the impact of p53 on gene expression in hematopoietic stem and progenitor cells.
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| |
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| Overall design |
Examination of histone modification H3K27me3 in p53+/+ and p53R248W/+ HSPCs (Lin-Kit+). Examine gene expression in p53+/+, p53R248W/+, and p53-/- HSPCs (LSKs)
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| |
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| Contributor(s) |
Chen S, Liu Y, Wang Q, Gao Z |
| Citation(s) |
31827082 |
| |
| Submission date |
Sep 09, 2019 |
| Last update date |
Dec 31, 2019 |
| Contact name |
Yan Liu |
| E-mail(s) |
[email protected]
|
| Phone |
3125031504
|
| Organization name |
Department of Medicine
|
| Department |
Pediatrics
|
| Street address |
303 E. Superior Street, Lurie 5-107, Northwestern University
|
| City |
Chicago |
| State/province |
IL |
| ZIP/Postal code |
60611 |
| Country |
USA |
| |
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| Platforms (2) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (11)
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| Relations |
| BioProject |
PRJNA564593 |
| SRA |
SRP221081 |
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