|
| Status |
Public on Sep 26, 2022 |
| Title |
Enhancing Acsl4 in absence of mTORC2/Rictor drove β-cell dedifferentiation via inhibiting FoxO1 and promoting ROS production |
| Organism |
Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
We here identified Acsl4, a new target of mTORC2, could rescue the impaired β cell proliferation, but not deficient insulin secretion induced by loss of Rictor.
|
| |
|
| Overall design |
ex vivo overexpression Acsl4 in βRicKO mice
|
| |
|
| Contributor(s) |
Cui C, Gu Y |
| Citation(s) |
34455055 |
| |
| Submission date |
Sep 25, 2019 |
| Last update date |
Dec 30, 2022 |
| Contact name |
canqi cui |
| E-mail(s) |
[email protected]
|
| Organization name |
shanghai national reaearch center for endocrine and metabolic diseases
|
| Street address |
197 Ruijin 2nd Road
|
| City |
Shanghai |
| ZIP/Postal code |
20025 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
|
| Samples (6)
|
|
| Relations |
| BioProject |
PRJNA574153 |
| SRA |
SRP223227 |
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