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| Status |
Public on Jun 22, 2020 |
| Title |
Comprehensive analysis of circRNA expression profiles and circRNA-associated ceRNA networks in age-related changes of mouse thymus |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
Non-coding RNA profiling by high throughput sequencing
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| Summary |
Our findings further expand the current knowledge regarding the biology of ceRNAs and their regulatory roles in thymic development and involution process. These newly discovered networks provide more ideas for further research about age-related thymic changes in the future.
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| Overall design |
we used miRNA sequencing and LncRNA sequencing to detect several time points in mouse thymic development (2, 6 weeks old and 3 months old) to study the underlying biological mechanisms in the rapid development of the thymus after birth (from 2 weeks old to 6 weeks old) and the subsequent decline process (from 6 weeks old to 3 months old).
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| Contributor(s) |
Zhang W, Wan J, Li W, Ma N |
| Citation(s) |
32307889 |
| |
| Submission date |
Oct 31, 2019 |
| Last update date |
Jun 22, 2020 |
| Contact name |
Wen Ting Li |
| E-mail(s) |
[email protected]
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| Organization name |
Shenzhen PKU-HKUST Medical Center
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| Street address |
No,1120,LianHua Road,FuTian District
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| City |
Shenzhen |
| ZIP/Postal code |
518000 |
| Country |
China |
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| Platforms (2) |
| GPL17021 |
Illumina HiSeq 2500 (Mus musculus) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA586829 |
| SRA |
SRP227793 |
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