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| Status |
Public on Jun 29, 2020 |
| Title |
Photothermal Modulation of Human Stem Cells Using Light-responsive 2D Nanomaterials |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Two-dimensional (2D) molybdenum disulfide (MoS2) nanomaterials are an emerging class of biomaterials that are photo-responsive at near-infrared wavelengths (NIR). Here, we demonstrate for the first time the ability of 2D MoS2 to modulate cellular functions of human stem cells through photothermal mechanisms. The interaction of MoS2 with human stem cells is investigated using whole transcriptome sequencing (RNA-seq). Global gene expression profile of stem cells reveals significant influence by NIR stimulation of MoS2 on integrins, cellular migration and wound healing. Overall, the combination of MoS2 and NIR light may provide new approach to control and regulate cellular migration and functions.
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| |
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| Overall design |
Examination of effect of MoS2 and NIR on human mesenchymal stem cells (hMSCs)
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| |
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| Contributor(s) |
Jake CK, Kanwar SA, Irtisha S, Akhilesh GK |
| Citation(s) |
32461372 |
| |
| Submission date |
Dec 04, 2019 |
| Last update date |
Jun 29, 2020 |
| Contact name |
Irtisha Singh |
| E-mail(s) |
[email protected]
|
| Organization name |
Texas A&M Health Science Center
|
| Street address |
8447 Riverside Pkwy Medical Research and Education Building II
|
| City |
Bryan |
| State/province |
TX |
| ZIP/Postal code |
77807 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA593516 |
| SRA |
SRP234710 |
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