NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE148263 Query DataSets for GSE148263
Status Public on Sep 18, 2020
Title The ubiquitin ligase TRIM37 controls cancer-specific vulnerability to PLK4 inhibition
Organism Homo sapiens
Experiment type Expression profiling by high throughput sequencing
Summary We show synthetic lethality between PLK4 inhibition-mediated centrosome loss and the overexpression of the ubiquitin ligase TRIM37 in cancer cells with amplification of Chr17q
 
Overall design Compare the effect of differential TRIM37 expression on global gene expression in untransformed hTERT RPE1 and neuroblastoma CHP-134 cells.
 
Contributor(s) Meitinger F, Desai A, Oegema K
Citation(s) 32908304
Submission date Apr 07, 2020
Last update date Sep 18, 2020
Contact name Karen Oegema
E-mail(s) [email protected]
Organization name UCSD
Street address 9500 Gilman Drive, CMM East
City San Diego
State/province California
ZIP/Postal code 92093
Country USA
 
Platforms (1)
GPL20301 Illumina HiSeq 4000 (Homo sapiens)
Samples (39)
GSM4458921 RPE1 rep1-1
GSM4458922 RPE1 rep1-2
GSM4458923 RPE1 rep1-3
Relations
BioProject PRJNA623614
SRA SRP255637

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE148263_CHP134-TRIM37ko-31-ODCL0088.csv.gz 277.9 Kb (ftp)(http) CSV
GSE148263_CHP134-TRIM37ko-63-ODCL0092.csv.gz 281.8 Kb (ftp)(http) CSV
GSE148263_RPE1-TRIM37ko-ODCL0061.csv.gz 285.4 Kb (ftp)(http) CSV
GSE148263_RPE1-TRIM37oe-13-ODCL0082.csv.gz 262.8 Kb (ftp)(http) CSV
GSE148263_RPE1-TRIM37oe-16-ODCL0083.csv.gz 263.5 Kb (ftp)(http) CSV
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap