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| Status |
Public on Apr 10, 2020 |
| Title |
Eye-antenna early L3 disc expression profiling in combinations of COX7a-LoF, ATF4-LoF and Notch-GoF |
| Organism |
Drosophila melanogaster |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Gene expression in larval, early third instar eye-antenna discs was assessed to reveal an ATF4 contribution to target gene induction following COX7a knockdown. As hypothesised, these COX7a-RNAi induced target genes require the transcription factor ATF4 for induction, irrespective of concomitant Notch pathway activation through Delta over-expression.
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| Overall design |
Two biological replicates for eight genotypes were analysed (sixteen samples in total)
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| Contributor(s) |
Sorge S, Theelke J, Yildirim K, Hertenstein H, McMullen E, Müller S, Altbürger C, Schirmeier S, Lohmann I |
| Citation(s) |
32433968 |
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| Submission date |
Apr 09, 2020 |
| Last update date |
Aug 13, 2020 |
| Contact name |
Sebastian Sorge |
| E-mail(s) |
[email protected]
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| Organization name |
The Francis Crick Institute
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| Street address |
1 Midland Road
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| City |
London |
| ZIP/Postal code |
NW1 1AT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL1322 |
[Drosophila_2] Affymetrix Drosophila Genome 2.0 Array |
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| Samples (16)
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| GSM4468636 |
eL3_EAD_NR_ey>Delta,GFP_rep2 |
| GSM4468637 |
eL3_EAD_NR_ey>GFP_rep1 |
| GSM4468638 |
eL3_EAD_NR_ey>GFP_rep2 |
| GSM4468639 |
eL3_EAD_NR_ey>COX7aRNAi,ATF4RNAi_rep1 |
| GSM4468640 |
eL3_EAD_NR_ey>COX7aRNAi,ATF4RNAi_rep2 |
| GSM4468641 |
eL3_EAD_NR_ey>Delta,COX7aRNAi,ATF4RNAi_rep1 |
| GSM4468642 |
eL3_EAD_NR_ey>Delta,COX7aRNAi,ATF4RNAi_rep2 |
| GSM4468643 |
eL3_EAD_NR_ey>Delta,COX7aRNAi_rep1 |
| GSM4468644 |
eL3_EAD_NR_ey>Delta,COX7aRNAi_rep2 |
| GSM4468645 |
eL3_EAD_ey>Delta,ATF4RNAi_rep1 |
| GSM4468646 |
eL3_EAD_NR_ey>Delta,ATF4RNAi_rep2 |
| GSM4468647 |
eL3_EAD_NR_ey>COX7aRNAi_rep1 |
| GSM4468648 |
eL3_EAD_NR_ey>COX7aRNAi_rep2 |
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| Relations |
| BioProject |
PRJNA624157 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE148414_RAW.tar |
33.9 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
| Processed data included within Sample table |
| Processed data provided as supplementary file |
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